{"id":87641,"date":"2000-01-12T00:00:00","date_gmt":"2000-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-oxido-nitrico-en-la-inflamacion-intestinal-y-su-interes-en-terapeutica\/"},"modified":"2000-01-12T00:00:00","modified_gmt":"2000-01-12T00:00:00","slug":"papel-del-oxido-nitrico-en-la-inflamacion-intestinal-y-su-interes-en-terapeutica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-oxido-nitrico-en-la-inflamacion-intestinal-y-su-interes-en-terapeutica\/","title":{"rendered":"Papel del oxido nitrico en la inflamacion intestinal y su interes en terapeutica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Vera Gonzalez <\/strong><\/h2>\n<p>El objetivo de esta tesis doctoral es dilucidar el mecanismo de acci\u00f3n antiinflamatorio intestinal de la quercitrina, intentando profundizar en el posible papel que la inhibici\u00f3n en la formaci\u00f3n de no puede jugar en este mecanismos.  para llevar a cabo este objetivo nos hemos planteado el siguiente plan de trabajo:  1-investigar el papel que juega el no en las etapas iniciales del proceso inflamatorio inducido por tnbs en ratas. Uno de los modelos experimentales mas aceptados, ya que reproduce en gran medida los procesos implicados en esta patolog\u00eda en humanos.  2-estudiar el efecto de la quercitrina en dos modelos de inflamaci\u00f3n intestinal en ratas inducido por tnbs y por pma.  las conclusiones a las que hemos llegado han sido:  1-la producci\u00f3n de no col\u00f3nico se encuentra elevada tanto en las etapas iniciales como en las cronicas del modelo de colitis inducido por 30 mg de tnbs.  2-el incremento en la producci\u00f3n de no es, en parte, el responsable de la alteraci\u00f3n en la reactividad vascular mesent\u00e9rica que se produce en las etapas iniciales del proceso inflamatorio. Sin embargo, este aumento no justificar\u00eda la alteraci\u00f3n en el transporte electrol\u00edtico que se origina en este modelo de inflamaci\u00f3n.  3-el efecto antiinflamatorio de la quercitrina a la dosis de 1 mg\/kg se puede justificar por su acci\u00f3n antirradicalaria y por la mejora en la funcionalidad intestinal.  4-la quercitrina a la dosis de 5 mg\/kg mejora la alteraci\u00f3n de la reactividad vascular que se produce durante las etapas iniciales del proceso inflamatorio. este efecto beneficioso parece estar relacionado con la inhibici\u00f3n en la producci\u00f3n de no en el territorio vascular mesent\u00e9rico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del oxido nitrico en la inflamacion intestinal y su interes en terapeutica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del oxido nitrico en la inflamacion intestinal y su interes en terapeutica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Vera Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zarzuelo Zurita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Jim\u00e9nez mart\u00edn <\/li>\n<li>Miguel Pay\u00e1 peris (vocal)<\/li>\n<li>elisa Marhuenda requena (vocal)<\/li>\n<li>Manuel Merlos roca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Vera Gonzalez El objetivo de esta tesis doctoral es dilucidar el mecanismo de acci\u00f3n antiinflamatorio intestinal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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