{"id":87652,"date":"2000-01-12T00:00:00","date_gmt":"2000-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fracaso-renal-agudo-en-ratas-prepuberes-efecto-terapeutico-del-factor-de-crecimiento-semejante-a-insulina-tipo-i-igf-i\/"},"modified":"2000-01-12T00:00:00","modified_gmt":"2000-01-12T00:00:00","slug":"fracaso-renal-agudo-en-ratas-prepuberes-efecto-terapeutico-del-factor-de-crecimiento-semejante-a-insulina-tipo-i-igf-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/fracaso-renal-agudo-en-ratas-prepuberes-efecto-terapeutico-del-factor-de-crecimiento-semejante-a-insulina-tipo-i-igf-i\/","title":{"rendered":"\u00abfracaso renal agudo en ratas prep\u00faberes. efecto terap\u00e9utico del factor de crecimiento semejante a insulina tipo i (igf-i)\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Medina Villanueva <\/strong><\/h2>\n<p>Los estudios desarrollados sobre modelos experimentales de fracaso renal agudo(fra) isqu\u00e9mico se han realizado utilizando animales adultos. Es previsible que la respuesta de los animales j\u00f3venes a la agresi\u00f3n isqu\u00e9mica sea distinta a la observada en animales adultos. Considerando que un modelo de fra isqu\u00e9mico en animales de experimentaci\u00f3n j\u00f3venes permitir\u00eda una mejor aproximaci\u00f3n a los mecanismos fisiopatol\u00f3gicos del fra que se presenta habitualmente en lactantes y ni\u00f1os de corta edad, el primer objetivo de este estudio fue caracterizar en detalle la evoluci\u00f3n del fra en animales en fase de crecimiento r\u00e1pido inducido por diferentes periodos de isquemia (60,75 y 90 minutos). Se analiz\u00f3 la mortalidad, la evoluci\u00f3n diaria del nitr\u00f3geno ur\u00e9ico s\u00e9rico, la creatinina y el paso corporal y se valor\u00f3 el da\u00f1o renal y la proliferaci\u00f3n celular a las 48 horas y a los 7 d\u00edas de la isquemia-reperfusi\u00f3n.  en la actualidad se discute la utilidad del tratamiento del fra con distintos factores de crecimiento, en especial el igf-i. Dado que no existen datos bibliogr\u00e1ficos a cerca de efecto del igf-i en la evolucion del fra en animales j\u00f3venes sometidos a isquemia renal, el segundo objetivo planteado en este trabajo fue verificar si el tratamiento con igf-i mejora la evoluci\u00f3n del fra en estos animales. Para ello se estudiaron ratas j\u00f3venes sometidas a 75 minutos de isquemia renal sometidas a tratamiento con igf-i o placebo. adem\u00e1s de caracterizar la mortalidad, la funci\u00f3n renal y el da\u00f1o histol\u00f3gico, se valoro:infiltraci\u00f3n de neutr\u00f3filos a las 48 horas y a los 7 dias.  el pinzamiento bilateral de los ped\u00edculos renales durante 60.75 y 90 minutos permiti\u00f3 caracterizar tres modelos diferentes de fra en base a criterios cl\u00ednico-patol\u00f3gicos. El tratamiento con ifg-i no produjo ning\u00fan efecto beneficioso en el modelo de fra de 75 minutos de isquemia renal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abfracaso renal agudo en ratas prep\u00faberes. efecto terap\u00e9utico del factor de crecimiento semejante a insulina tipo i (igf-i)\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abfracaso renal agudo en ratas prep\u00faberes. efecto terap\u00e9utico del factor de crecimiento semejante a insulina tipo i (igf-i)\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Medina Villanueva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Santos Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Crespo hernandez <\/li>\n<li>victor Garcia nieto (vocal)<\/li>\n<li>Andr\u00e9s Sampedro nu\u00f1o (vocal)<\/li>\n<li>Fernando Lia\u00f1o Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Medina Villanueva Los estudios desarrollados sobre modelos experimentales de fracaso renal agudo(fra) isqu\u00e9mico se han realizado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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