{"id":87755,"date":"2000-05-12T00:00:00","date_gmt":"2000-05-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetica-de-la-produccion-de-acido-clavulanico-en-streptomyces-clavuligerus\/"},"modified":"2000-05-12T00:00:00","modified_gmt":"2000-05-12T00:00:00","slug":"genetica-de-la-produccion-de-acido-clavulanico-en-streptomyces-clavuligerus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/genetica-de-la-produccion-de-acido-clavulanico-en-streptomyces-clavuligerus\/","title":{"rendered":"Gen\u00e9tica de la producci\u00f3n de \u00e1cido clavul\u00e1nico en streptomyces clavuligerus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Del Rosario P\u00e9rez Redondo <\/strong><\/h2>\n<p>En streptomyces clavuligerus la agrupaci\u00f3n biosint\u00e9tica de \u00e1cido clavul\u00e1nico, un inhibidor de b-lactamasas, est\u00e1 situada corriente debajo de los genes de bios\u00edntesis de cefamicina c. En el trabajo se muestra la carcterizaci\u00f3n de una regi\u00f3n de aproximadamente 12 kb de extensi\u00f3n que contiene la mayor parte de la informaci\u00f3n necesaria para la bios\u00edntesis de \u00e1cido clavul\u00e1nico. de los ocho marcos de lectura contenidos en el fragmento analizado se profundiza en el estudio de cuatro de ellos. El gen pyc codifica la prote\u00edna que condensa los dos percusores de la mol\u00e9cula de \u00e1cido clavul\u00e1nico, arginina y glicerdeh\u00eddo-3-fosfato. La interrupci\u00f3n de este gen condiciona la producci\u00f3n de \u00e1cido clavul\u00e1nico al medio de cultivo utilizado, lo que apunta a la existencia de un duplicado g\u00e9nico de pyc.  orf-6 codifica una prote\u00edna hom\u00f3loga de ornitina acetilfransfereasa, enzimas implicadas en la bios\u00edntesis del precursor arginina.La interrupci\u00f3n de orf-6 afecta negativamente a la producci\u00f3n de \u00e1cido clavul\u00e1nico. Hemos determinado que este gen se halla bajo el control transcripcional negativo ejercido por argr, el represor de la bios\u00edntesis de arginina.  car codifica la enzima responsable del \u00faltimo paso biosint\u00e9tico: la reducci\u00f3n del clavulanato-9-aldeh\u00eddo a \u00e1cido clavul\u00e1nico. La inactivaci\u00f3n de este gen imposibilita la producic\u00f3n de \u00e1cido clavul\u00e1nico.  clar codifica un activador transcripcional. Se ha desmostrado que controla la transcripci\u00f3n de los genes biosint\u00e9ticos orf-6 y car y que, est\u00e1 controlado por el regulador superiro de cefamicina c y \u00e1cido clavul\u00e1nico, ccar.Seg\u00fan los experimentos de inactivaci\u00f3n y amplificaci\u00f3n g\u00e9nicas, clar regula positivamente la producci\u00f3n de \u00e1cido clavul\u00e1nico.  adem\u00e1s, se han realizado an\u00e1lisis de los transcritos correspondientes al regulador clar y a los genes estructurales tard\u00edos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Gen\u00e9tica de la producci\u00f3n de \u00e1cido clavul\u00e1nico en streptomyces clavuligerus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Gen\u00e9tica de la producci\u00f3n de \u00e1cido clavul\u00e1nico en streptomyces clavuligerus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Del Rosario P\u00e9rez Redondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Liras Pad\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Francisco Mart\u00edn mart\u00edn <\/li>\n<li>Francisco Malpartida romero (vocal)<\/li>\n<li>Antonio Jimenez-Martinez (vocal)<\/li>\n<li>Jos\u00e9 Luis Barredo fuente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Rosario P\u00e9rez Redondo En streptomyces clavuligerus la agrupaci\u00f3n biosint\u00e9tica de \u00e1cido clavul\u00e1nico, un inhibidor de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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