{"id":87803,"date":"2000-11-12T00:00:00","date_gmt":"2000-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-y-significado-de-los-anta%c2%adgenos-hla-ab-dr-y-dq-en-los-pacientes-con-artritis-cronica-juvenil-poliarticular-acj\/"},"modified":"2000-11-12T00:00:00","modified_gmt":"2000-11-12T00:00:00","slug":"estudio-y-significado-de-los-anta%c2%adgenos-hla-ab-dr-y-dq-en-los-pacientes-con-artritis-cronica-juvenil-poliarticular-acj","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-y-significado-de-los-anta%c2%adgenos-hla-ab-dr-y-dq-en-los-pacientes-con-artritis-cronica-juvenil-poliarticular-acj\/","title":{"rendered":"Estudio y significado de los ant\u00edgenos hla a,b, dr y dq en los pacientes con artritis cr\u00f3nica juvenil poliarticular (acj)"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Duarte De Laterza M. Margarita <\/strong><\/h2>\n<p>Objetivos  analizar las caracter\u00edsticas cl\u00ednicas de la acj en nuestra poblaci\u00f3n de pacientes y establecer una correlaci\u00f3n entre las formas cl\u00ednicas de la acj y los ant\u00edgenos hla.  material y metodos  se incluyeron 125 pacientes con acj controlados en la consulta externa del hospital valle de hebr\u00f3n, de los cuales 78 presentaron un inicio oligoarticualar, 26 un inicio poliarticular y 21 un inicio sist\u00e9mico. La determinaci\u00f3n de los ant\u00edgenos del grupo a y b se realiz\u00f3 por microlinfocitotoxicidad y la de los grupos dr y dq por pcr-sso. Los controles fueron 130 donantes voluntarios del banco de tejidos de barcelona. Se realiz\u00f3 la correcci\u00f3n de la p seg\u00fan el n\u00famero de comparaciones hechas.  resultados cl\u00ednicos  en el grupo de pacientes oligoariculares hemos encontrado un aumento significativo de la frecuencia de los ana, mientras que en el grupo de inicio poliarticualr del fr. Entre los pacientes sist\u00e9micos, el 95% presentron ana, fr y b27(-). La preValencia de uve\u00edtis cr\u00f3nica es del 21% en los oligoarticulares, mientras que la uve\u00edtis aguda del 4%.  resultados gen\u00e9ticos  en el grupo pacientes oligoarticulares, encontramos un aumento significativo de la frecuencia del ant\u00edgeno hla drb1* 0801 en comparaci\u00f3n con los controles (26% vs 4%). En los pacientes oligoarticulares que iniciaron la enfermedad antes de los 6 a\u00f1os, se observ\u00f3 adem\u00e1s un aumento significativo del hla dr11 (51% vs 19%) y una disminuci\u00f3n significativa del hla drb1* 0701 (7% vs 35%). En los ni\u00f1os con inicio de la enfermedad entre los 6 y 15 a\u00f1os, encontramos un aumento significativo del hlab27 (39% vs 7%). No encontramos diferencias significativas con los controles en los grupos poliarticular y sist\u00e9mico.  conclusiones  en la forma de inicio oligoarticular, existen dos formas cl\u00ednicas bien definidas: los que iniciaron la enfermedad antes de los 6 a\u00f1os, que se caracterizan por un aumento de los ant\u00edgenos hla dr8 y hla dr 11 y una dism<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio y significado de los ant\u00edgenos hla a,b, dr y dq en los pacientes con artritis cr\u00f3nica juvenil poliarticular (acj)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio y significado de los ant\u00edgenos hla a,b, dr y dq en los pacientes con artritis cr\u00f3nica juvenil poliarticular (acj) <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Duarte De Laterza M. Margarita <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicen\u00c1\u00a7 Fonollosa Pla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>sim\u00f3 Schwartz riera (vocal)<\/li>\n<li>enric Lience dur\u00e1n (vocal)<\/li>\n<li>joan Ca\u00f1ete crespillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Duarte De Laterza M. Margarita Objetivos analizar las caracter\u00edsticas cl\u00ednicas de la acj en nuestra poblaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[4229,35,9,962,1820,1737,139,877],"tags":[183572,1208,183574,13703,14062,183573],"class_list":["post-87803","post","type-post","status-publish","format-standard","hentry","category-anticuerpos-de-tejidos","category-ciencias-de-la-vida","category-ciencias-medicas","category-genetica","category-genetica-de-poblaciones","category-inmunologia","category-medicina-interna","category-reumatologia","tag-duarte-de-laterza-m-margarita","tag-enric-lience-duran","tag-joan-canete-crespillo","tag-miquel-vilardell-tarres","tag-simo-schwartz-riera","tag-vicena-fonollosa-pla"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87803"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87803\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}