{"id":87825,"date":"2000-12-12T00:00:00","date_gmt":"2000-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-bioqua%c2%admicas-y-estructurales-vasculares-en-la-diabetes-aumento-de-la-s-nitrosilacion-de-la-hemoglobina-glicada\/"},"modified":"2000-12-12T00:00:00","modified_gmt":"2000-12-12T00:00:00","slug":"alteraciones-bioqua%c2%admicas-y-estructurales-vasculares-en-la-diabetes-aumento-de-la-s-nitrosilacion-de-la-hemoglobina-glicada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-bioqua%c2%admicas-y-estructurales-vasculares-en-la-diabetes-aumento-de-la-s-nitrosilacion-de-la-hemoglobina-glicada\/","title":{"rendered":"Alteraciones bioqu\u00edmicas y estructurales vasculares en la diabetes. aumento de la s-nitrosilaci\u00f3n de la hemoglobina glicada"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Padr\u00f3n Vel\u00e1zquez Julio L\u00e1zaro <\/strong><\/h2>\n<p>La vasculopat\u00eda perif\u00e9rica, por su \u00edndice de morbi-mortalidad, constituye una de las m\u00e1s serias complicaciones de la diabetes mellitus, que llega a afectar a alrededor de un 5% de la poblaci\u00f3n mundial.  en primer lugar se aborda la vasculopat\u00eda diab\u00e9tica explorando el v\u00ednculo entre los mediadores que se le han relacionado durante los \u00faltimos a\u00f1os; la hemoglobina glicada y el \u00f3xido n\u00edtrico. Se buscaba una alteraci\u00f3n en la recientemente descrita capacidad de la hemoglobina para transportar \u00f3xido n\u00edtrico como mecanismo de control del tono vascular y la irrigaci\u00f3n de tejidos. En este sentido, los resultados obtenidos estudiando in vitro la s-nitrosilaci\u00f3n de la hemoglobina humana control y glicada frente a diversos s-nitroso donadores, permiten sugerir que, en efecto, la hemoglobina glicada, presente en altos niveles en individuos diab\u00e9ticos, es m\u00e1s susceptible a la s-nitrosilaci\u00f3n y mucho m\u00e1s estable, y por consecuencia ser\u00e1 capaz de transportar menos \u00f3xido n\u00edtrico.  a continuaci\u00f3n, el estudio modelo de diabetes inducida por estreptozotocina en ratas, permite corroborar in vivo la existencia de un mayor nivel de s-nitroso hemoglobina en el grupo de ratas diab\u00e9ticas, en paralelo a la ocurrencia de significativas alteraciones histomofol\u00f3gicas del lecho vascular mesent\u00e9rico. El novedoso hallazgo de una posible alteraci\u00f3n en la biodisponibilidad de \u00f3xido n\u00edtrico como consecuencia de un desbalance en la s-nitrosilaci\u00f3n de la hemoglobina glicada, abre una posibilidad a nuevos enfoques en el entendimiento de la etiopatogenia de la vasculopat\u00eda diab\u00e9tica, que podr\u00eda conducir a nuevas herramientas cl\u00ednicas y\/o diagn\u00f3sticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones bioqu\u00edmicas y estructurales vasculares en la diabetes. aumento de la s-nitrosilaci\u00f3n de la hemoglobina glicada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones bioqu\u00edmicas y estructurales vasculares en la diabetes. aumento de la s-nitrosilaci\u00f3n de la hemoglobina glicada <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Padr\u00f3n Vel\u00e1zquez Julio L\u00e1zaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos F\u00e9lix S\u00e1nchez Ferrer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar del fresno <\/li>\n<li>pedro S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>Javierfrancisco Regadera gonz\u00e1lez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Padr\u00f3n Vel\u00e1zquez Julio L\u00e1zaro La vasculopat\u00eda perif\u00e9rica, por su \u00edndice de morbi-mortalidad, constituye una de las m\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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