{"id":87833,"date":"2000-12-12T00:00:00","date_gmt":"2000-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-anticonvulsionantes-y-neurotoxicas-entre-antieplitepticos-tras-dosis-unicas-en-ratones\/"},"modified":"2000-12-12T00:00:00","modified_gmt":"2000-12-12T00:00:00","slug":"interacciones-anticonvulsionantes-y-neurotoxicas-entre-antieplitepticos-tras-dosis-unicas-en-ratones","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interacciones-anticonvulsionantes-y-neurotoxicas-entre-antieplitepticos-tras-dosis-unicas-en-ratones\/","title":{"rendered":"Interacciones anticonvulsionantes y neurotoxicas entre antieplitepticos tras dosis unicas en ratones."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Cuadrado Lavin <\/strong><\/h2>\n<p>Introduccion:  la monoterapia conantiepil\u00e9pticos es eficaza en el 50-80% de los pacientes (dependiendo del tipo de epilepsia), pero queda un 20-50% de los pacientes, en los que no consigue suprimir las crisis o lo hace a costa de efectos secundarios inaceptables, que podr\u00edan beneficiarse de una politerapia racional.  objetivos:  identificar en el rat\u00f3n las asociaciones de antiepil\u00e9pticos con un perifel favorable, es decir que mejoran la eficacia m\u00e1s que la toxicidad, como referencia inicial para el dise\u00f1o de posteriores ensayos cl\u00ednicos.  metodos:  se han estudiado las interacciones dos a dos de un antiepil\u00e9ptico cl\u00e1sico de amplio espectro (valproato=vpa), dos nuevos de amplio espectro (felbamato=fbm y lamotrigina=ltg) y dos de espectro reducido (gabapentina=gbp y vigabatrina =vgb). En primer lugar se estudi\u00f3 la influencia de asociar una dosis baja e ineficaz de un antipil\u00e9ptico sobre el efecto anticonvulsionante de dosis crecientes de otro frente al tonus por 4-aminopiridina (4ap), el clomus pentilenterazol (ptz) y el clonus por picrotoxina (pic) estim\u00e1ndose la de50 mediante el m\u00e9todo de litchfield-wilcoxon. En las asociaciones en las que se observ\u00f3 un aumento significativo de la potencia anticonvulsionante respecto a la monoterapia se estudi\u00f3 la neurotoxicidad (mediante el test del rotarod=rot) estim\u00e1ndose la dt50 y el \u00edndice terap\u00e9utico (dt50\/de50), las concentraciones cerebrales de fbm, ltg, vpa y vgb en cerebro total (para descartar que las interacciones tuvieran un origen farmacocin\u00e9ticos) y las concentraciones de gaba y glut\u00e1mico en cerebro total (para analizar su relaci\u00f3n conlos efectos anticonvulsionantes). Las asociaciones se consideraron beneficiosas cuando el cociente terap\u00e9utico (\u00edndice terap\u00e9utico en asociacion\/monoterapia) fue mayor de uno.  resultados:  en monoterapia el fbm produjo un efecto sigmoide completo frente a 4ap, ptz y rot y parcial frente a pic; la gbp produjo un efecto sigmoide<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones anticonvulsionantes y neurotoxicas entre antieplitepticos tras dosis unicas en ratones.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones anticonvulsionantes y neurotoxicas entre antieplitepticos tras dosis unicas en ratones. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Cuadrado Lavin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Armijo Simon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez beledo <\/li>\n<li>francesc Jan\u00e9 carrenca (vocal)<\/li>\n<li>Jos\u00e9 Luis Herranz fernandez (vocal)<\/li>\n<li>Rafael Palencia luaces (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Cuadrado Lavin Introduccion: la monoterapia conantiepil\u00e9pticos es eficaza en el 50-80% de los pacientes (dependiendo del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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