{"id":87834,"date":"2000-12-12T00:00:00","date_gmt":"2000-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-anticonvulsionante-de-la-vigabatrina-en-la-rata-e-interaccion-con-el-valproato\/"},"modified":"2000-12-12T00:00:00","modified_gmt":"2000-12-12T00:00:00","slug":"accion-anticonvulsionante-de-la-vigabatrina-en-la-rata-e-interaccion-con-el-valproato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/accion-anticonvulsionante-de-la-vigabatrina-en-la-rata-e-interaccion-con-el-valproato\/","title":{"rendered":"Accion anticonvulsionante de la vigabatrina en la rata e interaccion con el valproato"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cuevas Teran Isabel De Las <\/strong><\/h2>\n<p>Introduccion: existen pocos datos para fundamentar la asociacion racional de los antiepilepticos. La interaccion entre vigabatrina (vgb) y valproato (vpa), dos farmacos con mecanismos de acci\u00f3n complementarios, es dificil de estudiar por la falta de un modelo adecuado para valorar la accion anticonvulsionantes de la vgb. Objetivos: seleccionar un modelo de convulsiones para estudiar el efecto anticonvulsionante de la vgb en rata. Estudiar el efecto anticonvulsionante de la vgb y su interacci\u00f3n con el vpa en dicho modelo. Analizar la relaci\u00f3n entre los efectos anticonvulsionantes y los cambios en el gaba y glutamico cerebrales y descartar la posibilidad de interacciones farmacocineticas. metodos: el estudio se ha realizado en ratas sprague-dawley machos adultos. la accion anticonvulsionante de la vgb en monoterapia se ha estudiado frente a la incidencia y latencia de clonus y tonus en los modelos de picrotoxina (pcr), bibuculina (bic), lindano (lind), cimetidina (cim) y kainico (ka) tras dosis unicas (du) de 800 y 1600 mg\/kg a los 15 minutos, 4 horas y 24 horas de su administraci\u00f3n y tras dosis multiples (dm) de 50 a 800 mg\/kg solo en los modelos y a los tiempos en los que hubo eficacia. Tras seleccionar el modelo de la pcr, se estudi\u00f3 el efecto de dosis crecientes de vgb y vpa en monoterapia y en asociaci\u00f3n a los 15 minutos 4 horas y 24 horas tras du y dm. En series diferentes se determinaron el gaba, vgb y vpa en coliculo, mesencefalo, estriado, hipocampo, diencefalo y corteza cerebral y el glutamico (glu) en corteza a las dosis y tiempos en los que se vio un aumento del efecto anticonvulsionante. Resultados: la vgb en monoterapia no protegio totalmente frente a las convulsiones en ninguno de los modelos. el efecto anticonvulsionante vario en funcion del modelo de convulsiones, la dosis de vgb, el momento de la administracion, y entre du y dm. Tras du protegio a los 15 min. 4 h y 24 h. En los modelos de pcr,lind y ka y solo a las 24<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion anticonvulsionante de la vigabatrina en la rata e interaccion con el valproato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion anticonvulsionante de la vigabatrina en la rata e interaccion con el valproato <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cuevas Teran Isabel De Las <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Armijo Simon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez beledo <\/li>\n<li>Rafael Palencia luaces (vocal)<\/li>\n<li>francesc Jan\u00e9 carrenca (vocal)<\/li>\n<li>Jos\u00e9 Luis Herranz fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cuevas Teran Isabel De Las Introduccion: existen pocos datos para fundamentar la asociacion racional de los antiepilepticos. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,10518,9,2445,189,957],"tags":[183620,51,9872,28217,10699,12810],"class_list":["post-87834","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-cantabria","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacodinamia","category-farmacologia","tag-cuevas-teran-isabel-de-las","tag-francesc-jane-carrenca","tag-jesus-florez-beledo","tag-jose-luis-herranz-fernandez","tag-juan-antonio-armijo-simon","tag-rafael-palencia-luaces"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87834"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87834\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}