{"id":87889,"date":"2018-03-10T00:12:46","date_gmt":"2018-03-10T00:12:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estadiaje-molecular-del-cancer-de-prostata-mediante-el-ensayo-de-la-reaccion-en-cadena-de-la-polimerasa-con-transcripcion-reversa-de-anta%c2%adgeno-prostatico-especa%c2%adfico-rt-pcr-psa\/"},"modified":"2018-03-10T00:12:46","modified_gmt":"2018-03-10T00:12:46","slug":"estadiaje-molecular-del-cancer-de-prostata-mediante-el-ensayo-de-la-reaccion-en-cadena-de-la-polimerasa-con-transcripcion-reversa-de-anta%c2%adgeno-prostatico-especa%c2%adfico-rt-pcr-psa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estadiaje-molecular-del-cancer-de-prostata-mediante-el-ensayo-de-la-reaccion-en-cadena-de-la-polimerasa-con-transcripcion-reversa-de-anta%c2%adgeno-prostatico-especa%c2%adfico-rt-pcr-psa\/","title":{"rendered":"Estadiaje molecular del c\u00e1ncer de pr\u00f3stata mediante el ensayo de la reacci\u00f3n en cadena de la polimerasa con transcripci\u00f3n reversa de ant\u00edgeno prost\u00e1tico espec\u00edfico (rt-pcr psa)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Llanes Gonz\u00e1lez <\/strong><\/h2>\n<p>Objetivo: evaluar la utilidad cl\u00ednica de la detecci\u00f3n de c\u00e9lulas prost\u00e1ticas circulantes en sangre perif\u00e9rica de pacinetes con c\u00e1ncer de pr\u00f3stata mediante rt-pcr psa como predictor de enfermedad extraprost\u00e1tica y su correli\u00f3n con los factores predictivos establecidos de este status.  material y metodolog\u00eda: inmediatamente antes de la prostatectom\u00eda radical se tomaron muestras de sangre perif\u00e9rica de 25 pacientes con c\u00e1ncer de pr\u00f3stata cl\u00ednicamente localizado y se analiz\u00f3 la presencia de c\u00e9lulas prost\u00e1tica mediante rt-pcr psa en condiciones hot-start y confirmaci\u00f3n con el enzima de restricci\u00f3n cla i. Se calcul\u00f3 el l\u00edmite de detecci\u00f3n del ensayo de pcr mediante diluciones seriadas de c\u00e9lulas lncap en c\u00e9lulas mononucleares de sangre perif\u00e9rica. Las relaciones entre rt-pcr-psa y los rasgos cl\u00ednicos y patol\u00f3ngicos de los pacientes se analizaron. Finalmente se realiz\u00f3 una comparaci\u00f3n entre rt-pcr psa,psa y puntuaci\u00f3n gleason de la biopsia como predictores de enfermedad extraprost\u00e1tica.  adem\u00e1s, se tomaron dos grupos controles negativos constituidos por 20 varones con diagn\u00f3stico de hbp y por 20 mujeres.  resultados: en esta serie, no se observ\u00f3 asociaci\u00f3n estad\u00edsticamente significativa entre los resultados de la rt-pcr psa y el estadio local patol\u00f3gico pt2 o pt3. No se encontr\u00f3 ninguna asociaci\u00f3n entre la positividad de la rt-pcr psa y los niveles s\u00e9ricos de psa,psad, tacto rectal, volumen tumoral de la biopsia y la invasi\u00f3n perneural tumoral en la biopsia. Sin embargo,s\u00ed se encontr\u00f3 una asociaci\u00f3n estad\u00edsticamente significativa entre la puntuaci\u00f3n gleason de la biopsia y la positividad de la rt-pcr psa.  la comparaci\u00f3n de la rt-pcr psa como predictora independiente de c\u00e1ncer extraprost\u00e1tico con las modalidades de estadiaje preoperatorio aceptadas, psa&gt;10 y puntuaci\u00f3n gleason, tiene la sensibilidad (22,2%) y el valor predictivo positivo(28,6%) m\u00e1s bajos y no es factor de riesgo para enfe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estadiaje molecular del c\u00e1ncer de pr\u00f3stata mediante el ensayo de la reacci\u00f3n en cadena de la polimerasa con transcripci\u00f3n reversa de ant\u00edgeno prost\u00e1tico espec\u00edfico (rt-pcr psa)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estadiaje molecular del c\u00e1ncer de pr\u00f3stata mediante el ensayo de la reacci\u00f3n en cadena de la polimerasa con transcripci\u00f3n reversa de ant\u00edgeno prost\u00e1tico espec\u00edfico (rt-pcr psa) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Llanes Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Berenguer Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Resel est\u00e9vez <\/li>\n<li>joaqu\u00edn Carballido rodr\u00edguez (vocal)<\/li>\n<li>Francisco Javier Burgos revilla (vocal)<\/li>\n<li>Francisco Lovaco castellano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Llanes Gonz\u00e1lez Objetivo: evaluar la utilidad cl\u00ednica de la detecci\u00f3n de c\u00e9lulas prost\u00e1ticas circulantes en sangre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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