{"id":87900,"date":"2018-03-10T00:12:46","date_gmt":"2018-03-10T00:12:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-patogenicos-del-oxido-nitrico-en-la-infeccion-por-el-vih-1\/"},"modified":"2018-03-10T00:12:46","modified_gmt":"2018-03-10T00:12:46","slug":"aspectos-patogenicos-del-oxido-nitrico-en-la-infeccion-por-el-vih-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aspectos-patogenicos-del-oxido-nitrico-en-la-infeccion-por-el-vih-1\/","title":{"rendered":"Aspectos patogenicos del oxido nitrico en la infeccion por el vih-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josefa Gonzalez-nicolas Garrido <\/strong><\/h2>\n<p>Existen ciertas evidencias del papel patog\u00e9nico del tnf-a y del \u00f3xido n\u00edtrico (no) en la infecci\u00f3n pedi\u00e1trica por el vih principalmente relacionado con el sistema nervioso. En la cl\u00ednica habitual se utilizan marcadores inmunol\u00f3gicos y virol\u00f3gicos para el seguimiento de la infecci\u00f3n por el vih en ni\u00f1os en diferentes categorias clinicas (a: asintom\u00e1tica, b: s\u00edntomas leves y c s\u00edntomas severos o sida) e inmunol\u00f3gicas (categoria 1: cd4&gt;25%, 2:cd4 entre 15-25% y 3: cd4&lt;25%). Se ha estudiado la relaci\u00f3n existente entre el tnf-a y el no en relaci\u00f3n con el recuento de linfocitos tcd4+ y de la carga viral plasm\u00e1tica, adem\u00e1s de estudiar la relaci\u00f3n del no en aspectos de la patogenesis viral como su relaci\u00f3n con la replicaci\u00f3n del vih en linfocitos t y su relaci\u00f3n con la producci\u00f3n de citocinas.  los ni\u00f1os vih tienen valores plasm\u00e1ticos de tnf-a y no significativamente m\u00e1s altos que los ni\u00f1os controles no vih y el tratamiento antirretroviral disminuye los valores de tnf-a y no. La mayor producci\u00f3n de no est\u00e1 asociada a mayor replicaci\u00f3n viral y evoluci\u00f3n de la infecci\u00f3n y existe una fuerte correlaci\u00f3n entre las concentraciones plasmaticas de tnf-a y no en los ni\u00f1os vih+. Adem\u00e1s, el tnf-a aumenta la transcripci\u00f3n del ltr viral e induce la replicaci\u00f3n del vih-1 en linfocitos t v\u00eda no y la replicaci\u00f3n del vih en linfocitos t est\u00e1 controlada por la producci\u00f3n autocrina del tnf-a que, a su vez, induce a la enzima no sintasa inducible y la subsiguiente producci\u00f3n de no.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos patogenicos del oxido nitrico en la infeccion por el vih-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos patogenicos del oxido nitrico en la infeccion por el vih-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josefa Gonzalez-nicolas Garrido <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M. Angeles Mu\u00f1oz Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Fresno escudero <\/li>\n<li>gutierrez Dolores gurbindo (vocal)<\/li>\n<li>delgado Rosa garcia (vocal)<\/li>\n<li>ignacio Villa el\u00edzaga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josefa Gonzalez-nicolas Garrido Existen ciertas evidencias del papel patog\u00e9nico del tnf-a y del \u00f3xido n\u00edtrico (no) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,1737,156,2935],"tags":[183714,183713,17798,183712,30047,22625],"class_list":["post-87900","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-patologia","category-sindrome-de-inmunodeficiencia-adquirida","tag-delgado-rosa-garcia","tag-gutierrez-dolores-gurbindo","tag-ignacio-villa-elizaga","tag-josefa-gonzalez-nicolas-garrido","tag-m-angeles-munoz-fernandez","tag-manuel-fresno-escudero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87900"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87900\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}