{"id":87905,"date":"2018-03-10T00:12:46","date_gmt":"2018-03-10T00:12:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-un-nuevo-locus-capsular-de-streptococcus-pneumoniae\/"},"modified":"2018-03-10T00:12:46","modified_gmt":"2018-03-10T00:12:46","slug":"caracterizacion-de-un-nuevo-locus-capsular-de-streptococcus-pneumoniae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-un-nuevo-locus-capsular-de-streptococcus-pneumoniae\/","title":{"rendered":"Caracterizaci\u00f3n de un nuevo locus capsular de streptococcus pneumoniae"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Llull Pe\u00f1alba <\/strong><\/h2>\n<p>El tipo 37 de streptococcus pneumoniae sintetiza una c\u00e1psula formada por un homopolisac\u00e1rido de glucosa ramificado, siendo la estructura y composici\u00f3n m\u00e1s sencilla de las descritas hasta el momento entre los polisac\u00e1ridos capsulares de neumococo (se han descrito 90 tipos capsulares diferentes en s.Pneumoniae). La c\u00e1psula es el principal factor de virulencia de este microorganismo, ya que las estirpes que han perdido la capacidad de sintetizarla son pr\u00e1cticamente avirulentas ya que son fagocitadas r\u00e1pidamente por el sistema inmunitario del hu\u00e9sped. Dada la importancia de la c\u00e1psula, el estudio del tipo 37 parec\u00eda ser adecuado para aportar datos acerca de los procesos desconocidos de la s\u00edntesis capsular en este microorganismo. No obstante, el estudio del locus cap, responsable de la s\u00edntesis en los tipos capsulares estudiados hasta el momento, revel\u00f3 que este serotipo es un caso especial, ya que la s\u00edntesis capsular no est\u00e1 asociada a locus cap37, sino que \u00e9ste constituye el resto gen\u00e9tico del locus capsular de otro serotipo, el 33f. Los neumococos de tipo 37 son binarios genot\u00edpicos, puesto que conservan este locus cap37 cr\u00edptico y, adem\u00e1s, poseen un gen, tts, localizado en otra regi\u00f3n cromos\u00f3mica que es el verdadero responsable del s\u00edntesis de este homopolisac\u00e1rido. El gen tts codifica una enzima con actividad beta-glucosiltransferasa dual, para producir los dos tipos de enlace presentes en el polisac\u00e1rido. La enzima tts es una prote\u00edna asociada a la membrana que conserva su funcionalidad cuando se expresa en otros microorganismos gram-positivos. Las peculiaridades gen\u00e9ticas encontradas en el estudio del tipo 37 son extrapolables a todos los aislados de este serotipo, ya que todos ellos pertenecen a un \u00fanico clon que ha permanecido gen\u00e9ticamente estable a lo largo del tiempo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de un nuevo locus capsular de streptococcus pneumoniae<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de un nuevo locus capsular de streptococcus pneumoniae <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Llull Pe\u00f1alba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ernesto Garc\u00eda L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Barb\u00e9 Garc\u00eda <\/li>\n<li> S\u00e1nchez-puelles y gonz\u00e1lez-carvajal Jos\u00e9 M\u00aa (vocal)<\/li>\n<li>julio Casal lombos (vocal)<\/li>\n<li>Rafael Rotger anglada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Llull Pe\u00f1alba El tipo 37 de streptococcus pneumoniae sintetiza una c\u00e1psula formada por un homopolisac\u00e1rido de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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