{"id":87907,"date":"2018-03-10T00:12:46","date_gmt":"2018-03-10T00:12:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-melatonina-en-la-modulacion-del-sistema-somatostatinergico-cerebral-de-la-rata\/"},"modified":"2018-03-10T00:12:46","modified_gmt":"2018-03-10T00:12:46","slug":"papel-de-la-melatonina-en-la-modulacion-del-sistema-somatostatinergico-cerebral-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/papel-de-la-melatonina-en-la-modulacion-del-sistema-somatostatinergico-cerebral-de-la-rata\/","title":{"rendered":"Papel de la melatonina en la modulaci\u00f3n del sistema somatostatin\u00e9rgico cerebral de la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Izquierdo Claros Rosa M. <\/strong><\/h2>\n<p>La administraci\u00f3n de melatonina en una dosis \u00fanica disminuye la actividad adenilil ciclasa en la corteza frontoparietal de la rata. La melatonina no altera la subunidad catal\u00edtica de la adenilil ciclasa ni en la corteza frontoparietal ni en el hipocampo de la rata. Por otro lado, tanto el tratamiento con una sola dosis de melatonina como durante 4 d\u00edas aumenta la acumulaci\u00f3n de inositol 1,4,5-trifosfato en el hipocampo de la rata.  la administraci\u00f3n de melatonina en una sola dosis y a corto plazo aumenta la actividad del sistema receptor-efector de la somatostatina en la corteza frontoparietal de la rata, ya que incrementa el n\u00famero de receptores de somatostatina y el efecto inhibidor de la misma sobre la actividad adenilill ciclasa.  la administraci\u00f3n de melatonina a corto plazo sensibiliza el sistema adenilil ciclasa en la corteza frontoparietal de la rata. Es posible que este efecto se pueda relacionar con la disminuci\u00f3n de los niveles de las prote\u00ednas gialfa2 detectado en el presente estudio.  la administraci\u00f3n de melatonina en una sola dosis y a corto plaza disminuye la actividad del sistema somatostatin\u00e9rgico en el hipocampo de la rata, ya que reduce el n\u00famero de receptores de somatostatina, el efecto inhibidor de la misma sobre la actividad adenilil ciclasa y su efecto estimulador sobre la acumulaci\u00f3n de inositol 1,4,5-trifosfato.  los efectos opuestos de la melatonina sobre el sistema somatostatin\u00e9rgico en la corteza frontoparietal y en el hipocampo de la rata sugieren una especificidad regional en el efecto de la misma.  la melatonina parece reducir el n\u00famero de receptroes de somatostatina en el hipocampo a trav\u00e9s de su acci\u00f3n como antagonista de la calmodulina, dado los resultados obtenidos in vitro con el calmidazol y calmidazol m\u00e1s melatonina. Sin embargo, en corteza frontoparietal de rata no parece que la melatonina pueda ejercer sus efectos a trav\u00e9s de antagonizar la calmodulina.  tampoco parece que<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la melatonina en la modulaci\u00f3n del sistema somatostatin\u00e9rgico cerebral de la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la melatonina en la modulaci\u00f3n del sistema somatostatin\u00e9rgico cerebral de la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Izquierdo Claros Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Boyano Ad\u00e1nez M. Carmen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel P\u00e9rez albarsanz <\/li>\n<li>vicente Barrios sabador (vocal)<\/li>\n<li>Manuel Rodr\u00edguez puyol (vocal)<\/li>\n<li>edgardo Catal\u00e1n tobar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Izquierdo Claros Rosa M. La administraci\u00f3n de melatonina en una dosis \u00fanica disminuye la actividad adenilil ciclasa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,160,115,17],"tags":[31686,6086,183722,7410,23384,17611],"class_list":["post-87907","post","type-post","status-publish","format-standard","hentry","category-alcala","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-boyano-adanez-m-carmen","tag-edgardo-catalan-tobar","tag-izquierdo-claros-rosa-m","tag-manuel-rodriguez-puyol","tag-miguel-angel-perez-albarsanz","tag-vicente-barrios-sabador"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87907"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87907\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}