{"id":87952,"date":"2018-03-10T00:12:50","date_gmt":"2018-03-10T00:12:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alta-prevalencia-de-hiperhomocisteinemia-en-pacientes-alcoholicos-su-relacion-con-el-deficit-de-acido-folico-y-vitaminas-b12-y-b6-y-con-el-polimorfismo-c677t-del-gen-de-la-enzima-mthfr\/"},"modified":"2018-03-10T00:12:50","modified_gmt":"2018-03-10T00:12:50","slug":"alta-prevalencia-de-hiperhomocisteinemia-en-pacientes-alcoholicos-su-relacion-con-el-deficit-de-acido-folico-y-vitaminas-b12-y-b6-y-con-el-polimorfismo-c677t-del-gen-de-la-enzima-mthfr","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alta-prevalencia-de-hiperhomocisteinemia-en-pacientes-alcoholicos-su-relacion-con-el-deficit-de-acido-folico-y-vitaminas-b12-y-b6-y-con-el-polimorfismo-c677t-del-gen-de-la-enzima-mthfr\/","title":{"rendered":"Alta preValencia de hiperhomocisteinemia en pacientes alcoholicos. su relacion con el deficit de acido folico y vitaminas b12 y b6 y con el polimorfismo c677t del gen de la enzima mthfr"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Jos\u00e9 De La Vega Prieto <\/strong><\/h2>\n<p>La homociste\u00edna es un amino\u00e1cido, hom\u00f3logo a la ciste\u00edna, que se sintetiza en los vertebrados a partir de la metionima procedente de la lisis proteica. en el metabolismo de este amino\u00e1cido pintervienen enzimas que necesitan como cofactores diversos derivados de vitaminas como: fosfato de pidioxal (forma coenzim\u00e1tica d ela vitamina b6), metilcobalamina (forma coenzim\u00e1tica de la vitamina b12) y 5 metiltetrahidrofolato (forma coenzim\u00e1tica del \u00e1cido f\u00f3lico). Adem\u00e1s, interviene un enzima: metilentetrahidrofoltao reductasa, que enlos \u00faltimos a\u00f1os se ha descubierto que una mutaci\u00f3n en el gen que codifica para este enzima genera un polomorfismo en la poblaci\u00f3n (ct677) que presenta distinta susceptibilidad a presentar hipoerhomocisteinemia (sobre todo los homocigotos tt).  del correcto balance entre los procesos de s\u00edntesis y catabolismo depende la concentraci\u00f3nde homociste\u00edna sangu\u00ednea. Cuando  este equilibrio se rompe se produce hiperhomocistenemia, que se ha relacionado en lso \u00faltimos a\u00f1os con la aterosclerosis del territorio vascular de forma que en la \u00faltima d\u00e9cada son numerosos los estudios cl\u00ednicos y epidemiol\u00f3gicos que demuestran que la elevaci\u00f3n moderada de la concentraci\u00f3n de homociste\u00edna sangu\u00ednea es un factor de riesgo independiente de producir aterosclerosis del territorio vascular, tanto arterial como venoso.  los sujetos alcoh\u00f3licos, que son el objeto de este estudio, tienen predisposicic\u00f3n a tener hiperhomcisteinemia puesto que normalmente, sobre todo los bebedores cr\u00f3nicos y con cosnumo excesio, presentan desnutrici\u00f3n debida a la alimentaci\u00f3n irregular, a los problemas sociales y a las patolgo\u00edas org\u00e1ncias asociadas al consumo de alcohol. Estas desnutrici\u00f3n puede provocra carencias de las vitaminas nombradas anteriormente. Esto se suma a que la ingesta excesiva y cr\u00f3ncia de alcohol es capaz de ihibir la actividad de la metionina sintasa hep\u00e1tica, con lo cual el catabolismo de la homociste\u00edn<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alta preValencia de hiperhomocisteinemia en pacientes alcoholicos. su relacion con el deficit de acido folico y vitaminas b12 y b6 y con el polimorfismo c677t del gen de la enzima mthfr<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alta preValencia de hiperhomocisteinemia en pacientes alcoholicos. su relacion con el deficit de acido folico y vitaminas b12 y b6 y con el polimorfismo c677t del gen de la enzima mthfr <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Jos\u00e9 De La Vega Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Santolaria Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Hernandez nieto <\/li>\n<li>alicia Conde martel (vocal)<\/li>\n<li> Gonzalez de buitrago arriero Jos\u00e9 Manuel (vocal)<\/li>\n<li>victoriano Darias del castillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Jos\u00e9 De La Vega Prieto La homociste\u00edna es un amino\u00e1cido, hom\u00f3logo a la ciste\u00edna, que se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1104,160,467,9,9915,139,17,4248],"tags":[10384,9970,25826,9971,183798,17531],"class_list":["post-87952","post","type-post","status-publish","format-standard","hentry","category-aminoacidos","category-bioquimica","category-ciencias-de-la-nutricion","category-ciencias-medicas","category-la-laguna","category-medicina-interna","category-quimica","category-vitaminas-en-la-alimentacion","tag-alicia-conde-martel","tag-francisco-santolaria-fernandez","tag-gonzalez-de-buitrago-arriero-jose-manuel","tag-luis-hernandez-nieto","tag-m-jose-de-la-vega-prieto","tag-victoriano-darias-del-castillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87952"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87952\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}