{"id":87976,"date":"2018-03-10T00:12:50","date_gmt":"2018-03-10T00:12:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/antigenos-de-espermatozoide-y-su-papel-en-la-fecundacion-del-raton-posible-aplicacion-en-vacunas-de-control-de-la-fertilidad\/"},"modified":"2018-03-10T00:12:50","modified_gmt":"2018-03-10T00:12:50","slug":"antigenos-de-espermatozoide-y-su-papel-en-la-fecundacion-del-raton-posible-aplicacion-en-vacunas-de-control-de-la-fertilidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/antigenos-de-espermatozoide-y-su-papel-en-la-fecundacion-del-raton-posible-aplicacion-en-vacunas-de-control-de-la-fertilidad\/","title":{"rendered":"Antigenos de espermatozoide y su papel en la fecundaci\u00f3n del rat\u00f3n. posible aplicaci\u00f3n en vacunas de control de la fertilidad."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fuentes Maja M. Pilar <\/strong><\/h2>\n<p>Investigamos ant\u00edgenos de espermatozoide que intervengan en la fecundaci\u00f3n. seleccionamos tres anticuerpos monoclonales antiespermatozoide humano(vic-1,zap-7,crl-10) que reconocen antigenos en espermatozoides de rat\u00f3n, especificos de tejido. administramos vic-1,zap-7 o crl-10(1 mg) por inmunizaci\u00f3n pasiva, via intravaginal,para estudiar su efecto en la fecundacion in vivo del raton. Zap-7 y crl-10 aumentan la mortalidad embrionaria preimplantacional hasta un 50%. Vic-1 no tiene ningun efecto deletero. Crl-10 detecta una proteina de 76+-2 kda en extractos de espermatozoide capacitado de raton(1%sds; condiciones reductoras), por la tecnica de western blot. Investigamos tambien antigenos alternativos, con la colaboracion de la dra. Caroline osterhoff (universidad de hamburg, alemania). Utilizamos la proteina recombinante de la dra. Caroline osterhoff(universidad de hamburg, alemania). Utilizamos la proteina recombinante de he2 humana, y un peptico sintetico de he2(aminoacidos 15-28:gelrerapgqgtngc) para dise\u00f1ar una vacuna de control de la fertilidad. Los espermatozoides de raton tienen una proteina con epitopos comunes en la proteina he2 humana. Un epitopo se localiza en la secuencia de aminoacidos 15-28 de he2 humana(\u00abpeptido he\u00bb). Los ratones inmunizados con p\u00e9ptido he2 y adyuvante de freund tienen un 50% menos de embriones preimplantaciones viables, in vivo, que los ratones no inmunizados. En experimentos de bloqueo de la fecundacion in vitro de raton,demostramos que el peptido he2 participa en la adhesi\u00f3n del espermatozoide a la zona pelucida del ovocito. En las inmunizaciones, el uso de adyuvante de freund es preferible por via subcutanea que por via intraperitoneal, pues se obtienen titulos de anticuerpos mas elevados y con menos efectos secundarios. Hemos investigado otros adyuvantes menos t\u00f3xicos, en colaboracion con el dr. M. S\u00e1bes(universitat autonoma de barcelona) y el dr. P. Cooper (australian national university, canberra,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antigenos de espermatozoide y su papel en la fecundaci\u00f3n del rat\u00f3n. posible aplicaci\u00f3n en vacunas de control de la fertilidad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antigenos de espermatozoide y su papel en la fecundaci\u00f3n del rat\u00f3n. posible aplicaci\u00f3n en vacunas de control de la fertilidad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fuentes Maja M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paz Martinez Ramirez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesca Vidal dom\u00ednguez <\/li>\n<li>carles Morte marti (vocal)<\/li>\n<li>Marta Vives pi (vocal)<\/li>\n<li> Gris Martinez josep Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fuentes Maja M. Pilar Investigamos ant\u00edgenos de espermatozoide que intervengan en la fecundaci\u00f3n. seleccionamos tres anticuerpos monoclonales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1738,35,32218,4667,1737,2714],"tags":[87438,29340,183836,183837,29484,29235],"class_list":["post-87976","post","type-post","status-publish","format-standard","hentry","category-antigenos","category-ciencias-de-la-vida","category-formacion-de-anticuerpos","category-inmunizacion","category-inmunologia","category-vacunas","tag-carles-morte-marti","tag-francesca-vidal-dominguez","tag-fuentes-maja-m-pilar","tag-gris-Martinez-josep-maria","tag-marta-vives-pi","tag-paz-Martinez-ramirez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87976"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87976\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}