{"id":87996,"date":"2018-03-10T00:12:54","date_gmt":"2018-03-10T00:12:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-galenico-de-una-forma-farmaceutica-topica-lipsomada-del-acido-all-trans-retinoico\/"},"modified":"2018-03-10T00:12:54","modified_gmt":"2018-03-10T00:12:54","slug":"desarrollo-galenico-de-una-forma-farmaceutica-topica-lipsomada-del-acido-all-trans-retinoico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-galenico-de-una-forma-farmaceutica-topica-lipsomada-del-acido-all-trans-retinoico\/","title":{"rendered":"Desarrollo galenico de una forma farmaceutica topica lipsomada del \u00e1cido all-trans retinoico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alain Ramirez Dieguez <\/strong><\/h2>\n<p>Se dise\u00f1a y caracteriza una forma farmac\u00e9utica t\u00f3pica del \u00e1cido all-trans retinoico encapsulado en liposomas de l\u00edpidos del estrato c\u00f3rneo (llec) y vehiculizado en matrices pol\u00edmericas de carbopol(r) ultreztm 10 y acido hialur\u00f3nico.  en una primera etapa se estudia el comportamiento de flujo y las propiedades mec\u00e1nicas los sistemas gelificados simples y binarios de estos pol\u00edmeros en funci\u00f3n de las variables: concentraci\u00f3n de pol\u00edmero, ph, temperatura, tiempo de agitaci\u00f3n y concentraci\u00f3n de cosolventes.  como resultado del estudio de caracterizaci\u00f3n reol\u00f3gica se obtienen modelos emp\u00edricos, estad\u00edsticamente v\u00e1lidos, para la correlaci\u00f3n de los par\u00e1metros reol\u00f3gicos con dichas variables.  posteriormente, mediante ensayos in vitro, se demuestra que la permeabilidad del \u00e1cido all-trans (3h)-retinoico en piel abdominal de ratas es significativamente menor con las formulaciones que contienen:  a,- \u00e1cido hialur\u00f3nico  b,- el principio activo encapsulado en llec.  los resultados obtenidos evidencian que el \u00e1cido hialur\u00f3nico y la encapsulaci\u00f3n en llec modifican los par\u00e1metros de liberaci\u00f3n y difusi\u00f3n in vitro del \u00e1cido (3h)-retinoico y, en consecuencia, la distribuci\u00f3n del principio activo en los diferentes estratos de piel abdominal de rata. Se concluye, finalmente, que una formulaci\u00f3n dise\u00f1ada para reducir los efectos adversos del \u00e1cido retinoico, facilitando la concentraci\u00f3n del principio activo a nivel de las capas superficiales de la piel e induciendo la formaci\u00f3n de un dep\u00f3sito-reservorio del \u00e1cido all-trans retinoico, que prolongue la acci\u00f3n del principio activo en la piel, debe combinar dos factores fundamentales: el carbopol(r) ultrez tm 10 y el \u00e1cido hialur\u00f3nico en relaci\u00f3n polim\u00e9rica 10:1 a ph eud\u00e9rmico, y la encapsulaci\u00f3n del \u00e1cido all-trans retinoico en liposomas de l\u00edpidos del estrato c\u00f3rneo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo galenico de una forma farmaceutica topica lipsomada del \u00e1cido all-trans retinoico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo galenico de una forma farmaceutica topica lipsomada del \u00e1cido all-trans retinoico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alain Ramirez Dieguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fresno Contreras M. Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Sell\u00e9s flores <\/li>\n<li>M\u00aa antonia Camacho s\u00e1nchez (vocal)<\/li>\n<li>eduardo Mari\u00f1o hernandez (vocal)<\/li>\n<li>m. victoria Margarit bellver (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alain Ramirez Dieguez Se dise\u00f1a y caracteriza una forma farmac\u00e9utica t\u00f3pica del \u00e1cido all-trans retinoico encapsulado en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9,957,3304],"tags":[183860,4078,3012,85662,99465,27321],"class_list":["post-87996","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-medicas","category-farmacologia","category-preparacion-de-farmacos","tag-alain-ramirez-dieguez","tag-eduardo-marino-hernandez","tag-eugenio-selles-flores","tag-fresno-contreras-m-jose","tag-m-victoria-margarit-bellver","tag-ma-antonia-camacho-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87996"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87996\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}