{"id":87999,"date":"2018-03-10T00:12:54","date_gmt":"2018-03-10T00:12:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-un-agonista-adrenergico-beta-3-sobre-la-expresion-de-genes-relacionados-con-la-termogenesis-y-la-adipogenesis-en-un-modelo-de-obesidad-dieta-de-cafeteria\/"},"modified":"2018-03-10T00:12:54","modified_gmt":"2018-03-10T00:12:54","slug":"influencia-de-un-agonista-adrenergico-beta-3-sobre-la-expresion-de-genes-relacionados-con-la-termogenesis-y-la-adipogenesis-en-un-modelo-de-obesidad-dieta-de-cafeteria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-un-agonista-adrenergico-beta-3-sobre-la-expresion-de-genes-relacionados-con-la-termogenesis-y-la-adipogenesis-en-un-modelo-de-obesidad-dieta-de-cafeteria\/","title":{"rendered":"Influencia de un agonista adren\u00e9rgico beta 3 sobre la expresi\u00f3n de genes relacionados con la termog\u00e9nesis y la adipog\u00e9nesis en un modelo de obesidad (dieta de cafeter\u00eda)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Margareto Sanchez <\/strong><\/h2>\n<p>En el presente trabajose ha desarrollado un modelo animal de obesidad inducido por el consumo de una dieta de cafeter\u00eda. Una vez generado el modelo de obesidad, se investi\u00f3 la influencia de la dieta sobre par\u00e1metros sangu\u00edneos realcionados con el metabolismo gluc\u00eddico y lip\u00eddico as\u00ed como sobre la expresi\u00f3n de genes implicados en procesos como la termog\u00e9nesis y adipog\u00e9nesis. Por otro lado, se ha estudiado el efecto de la administraci\u00f3n de un agonsita adren\u00e9rgico b3 (tertatolol) sobre la expresi\u00f3n de genes relacionados con al termog\u00e9nesis, ucp1, ucp2 y ucp\u00c2\u00b7 en tejido adiposo blanco, pardo y m\u00fasculo esquel\u00e9tico, y con la adipog\u00e9nesis del tejido adiposo blanco (ppary, rxra, c\/ebpa y ap2).  la administraci\u00f3n de tertatolol a una dosis de 1 mg\/kg d\u00eda en ratas alimentadas con una dieta de cafeter\u00eda disminuy\u00f3 el peso corporal y los dep\u00f3sitos grasos, redujo los niveles circulantes de leptina, aumentando, adem\u00e1s , los niveles de glicerol en suero, probando as\u00ed el efecto lipol\u00edtico del f\u00e1rmaco. La temepratura corporal aument\u00f3 tras el tratamiento con tertatolol. este efecto parece estar mediado por el aumento de los niveles de expresi\u00f3n de ucp1 en tejido adiposo blanco y m\u00fasculo gastroenemius y de ucp2 en m\u00fasculo. tambi\u00e9n se detecto una disminuci\u00f3n de los niveles de expresi\u00f3n de genes implicados en la diferenciaci\u00f3n y desarrollo del tejido adipos o blanco (ppary, rxra y ap2), lo que indica que la administraci\u00f3n del agonista adren\u00e9rgico b3 tertatolol, fue capaz de inhibir la adipog\u00e9nesis de este tejido. En conclusi\u00f3n, el tertatolol constituye una posibilidad para el tratamiento de la obesidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de un agonista adren\u00e9rgico beta 3 sobre la expresi\u00f3n de genes relacionados con la termog\u00e9nesis y la adipog\u00e9nesis en un modelo de obesidad (dieta de cafeter\u00eda).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de un agonista adren\u00e9rgico beta 3 sobre la expresi\u00f3n de genes relacionados con la termog\u00e9nesis y la adipog\u00e9nesis en un modelo de obesidad (dieta de cafeter\u00eda). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Margareto Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alfredo Martinez Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  pilar Fernandez otero <\/li>\n<li>Mar\u00eda  del puy Portillo baquedano (vocal)<\/li>\n<li>Manuel roman Benito de las heras (vocal)<\/li>\n<li> Del barrio linares Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Margareto Sanchez En el presente trabajose ha desarrollado un modelo animal de obesidad inducido por el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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