{"id":88024,"date":"2018-03-10T00:12:54","date_gmt":"2018-03-10T00:12:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/penfigo-vulgar-estudio-de-la-via-de-fosfatidilinositol-45-bisfosfato-en-la-acantolisis-en-un-modelo-experimental-murino-analisis-de-fenotipo-linfomonocitario-en-sangre-periferica-de-pacientes\/"},"modified":"2018-03-10T00:12:54","modified_gmt":"2018-03-10T00:12:54","slug":"penfigo-vulgar-estudio-de-la-via-de-fosfatidilinositol-45-bisfosfato-en-la-acantolisis-en-un-modelo-experimental-murino-analisis-de-fenotipo-linfomonocitario-en-sangre-periferica-de-pacientes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/penfigo-vulgar-estudio-de-la-via-de-fosfatidilinositol-45-bisfosfato-en-la-acantolisis-en-un-modelo-experimental-murino-analisis-de-fenotipo-linfomonocitario-en-sangre-periferica-de-pacientes\/","title":{"rendered":"Penfigo vulgar: estudio de la via de fosfatidilinositol-4,5-bisfosfato en la acantolisis en un modelo experimental murino. analisis de fenotipo linfomonocitario en sangre periferica de pacientes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Sanchez-carpintero Abad <\/strong><\/h2>\n<p>Estudiamos la implicaci\u00f3n de la v\u00eda de los fosfoinos\u00edtidos en la acantolisis en el p\u00e9nfigo vulgar (pv), mediante experimentos de transferencia pasiva en ratones balb\/c, empleando igg purificada de pacientes con pv variedad cut\u00e1neo-mucosa y mucosa. Unicamente la administraci\u00f3n de igg de pv con afectaci\u00f3n cut\u00e1neo-mucosa indujo lesiones. Para su estudio previamente administramos intrad\u00e9rmicamente los siguientes inhibidores: geniste\u00edna, herbimicina a, bisindolilmaleimida, u-73122 y w-7. En todos los casos no apreci\u00f3 una inhibici\u00f3n de la acantolisis a pesar de detectarse dep\u00f3sitos de igg en el estudio de inmunofluorescencia directa(ifd). La administraci\u00f3n de los sueros de pv variedad mucosa no indujeron la enfermedad, independientemente de la dosis de anticuerpo administrado, del t\u00edtulo de anticuerpos o de la localizaci\u00f3n de la afectaci\u00f3n mucosa. El estudio de ifd fue negativo en todas estas muestras.  asimismo, se determin\u00f3 en la piel murina la expresi\u00f3n de la prote\u00edn-kinasa p125fak, mediante inmunohistoqu\u00edmica, observ\u00e1ndose su expresi\u00f3n en el interior de los queratinocitos, unicamente en los casos en los que se produjo acantolisis. la administraci\u00f3n de los inhibidores junto a igg de pv no indujo esta prote\u00edna.  se ha estudiado el fenotipo linfomonocitario de sangre perif\u00e9rica en 38 muestras obtenidas de 5 pacientes con pv cutaneo-mucoso y en 6 con variedad mucosa. En los casos con afectaci\u00f3n cut\u00e1neo-mucosa se observ\u00f3 un mayor porcentaje de c\u00e9lulas presentadoras de ant\u00edgenos, tanto monocitos que expresaban altos niveles de hla-dr como linfocitos b activados, junto a una disminuci\u00f3n de linfocitos t naive y de c\u00e9lulas cd8+cd11b, en comparaci\u00f3n con los pacientes con afectaci\u00f3n exclusiva de mucosas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Penfigo vulgar: estudio de la via de fosfatidilinositol-4,5-bisfosfato en la acantolisis en un modelo experimental murino. analisis de fenotipo linfomonocitario en sangre periferica de pacientes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Penfigo vulgar: estudio de la via de fosfatidilinositol-4,5-bisfosfato en la acantolisis en un modelo experimental murino. analisis de fenotipo linfomonocitario en sangre periferica de pacientes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Sanchez-carpintero Abad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustin Espa\u00f1a Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: natalia Mar\u00eda Lopez moratalia <\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez zabalza (vocal)<\/li>\n<li>Francisco Camacho mart\u00ednez (vocal)<\/li>\n<li>Jos\u00e9 Carlos Moreno gimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Sanchez-carpintero Abad Estudiamos la implicaci\u00f3n de la v\u00eda de los fosfoinos\u00edtidos en la acantolisis en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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