{"id":88042,"date":"2018-03-10T00:12:54","date_gmt":"2018-03-10T00:12:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-corriente-de-calcio-tipo-t-en-la-hipertrofia-cardiaca-experimental\/"},"modified":"2018-03-10T00:12:54","modified_gmt":"2018-03-10T00:12:54","slug":"estudio-de-la-corriente-de-calcio-tipo-t-en-la-hipertrofia-cardiaca-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-corriente-de-calcio-tipo-t-en-la-hipertrofia-cardiaca-experimental\/","title":{"rendered":"Estudio de la corriente de calcio tipo t en la hipertrofia cardiaca experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Rodriguez M. Luisa <\/strong><\/h2>\n<p>La hipertrofia ventricular izquierda es una respuesta adaptiva del coraz\u00f3n a una sobrepresi\u00f3n cr\u00f3nica, que aunque en un principio permite mantener la funci\u00f3n cardiaca, a lo largo plazo se asocia a un aumento de mortalidad. es un hecho probado, que el coraz\u00f3n hipertr\u00f3fico muestra diversas alteraciones tales como fibrosis, dipersi\u00f3n de la refractoriedad y cambios electrofisiol\u00f3gicos, que hacen al mismo m\u00e1s susceptible a las arritmias. Por otro lado, tambi\u00e9n se ha demostrado que el desarrollo de hipertrofia cardiaca, se caracteriza por una vuelta a patrones embrionarios, mediante la reexpresi\u00f3n de genes fetales y protooncogenes en el miocito adulto. \u00e9l canal de calcio tipo t (icat)se asocia a procesos de crecimiento y su mayor densidad en el tejido especializado en la conducci\u00f3n y en c\u00e9lulas autom\u00e1ticas, hace que se relacione a su vez, con la funci\u00f3n marcapasos cardiaca.  por todo lo expuesto anteriormente realizamos un estudio en ratas, a las cuales se las indujo una hipertrofia cardiaca mediante estenosis a\u00f3rtica abdominal. En las c\u00e9lulas ventriculares aisladas de corazones controles a hipertr\u00f3ficos disociados enzim\u00e1ticamente, tratamos de analizar la presencia de icat, profundizando en su caracterizaci\u00f3n y modulaci\u00f3n farmacol\u00f3gica.  los resultados mostraron que la corriente icat, \u00fanicamente est\u00e1 presente en corazones hipertr\u00f3ficos de rata, y no as\u00ed en situaci\u00f3n control. Esta corriente se caracteriz\u00f3 por su cin\u00e9tica, su dependencia de voltaje, su similar selectividad al bario frente al calcio y su potente bloqueo por niquel y mibefradilo. Adem\u00e1s presento una corriente ventana entre el intervalo de potenciales de- 60mv a -20 mv, lo que supone una corriente de entrada fluyendo en la fase final de meseta del potencial de acci\u00f3n, lo que favorecer\u00eda la aparici\u00f3n de arritmias por postdespolarizaciones tempranas, en el coraz\u00f3n hipertr\u00f3fico. Por \u00faltimo, icat se mostr\u00f3 susceptible  a la modulaci\u00f3n farmacol\u00f3gica<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la corriente de calcio tipo t en la hipertrofia cardiaca experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la corriente de calcio tipo t en la hipertrofia cardiaca experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Rodriguez M. Luisa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Delgado Canencia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fernandez <\/li>\n<li>soledad Fernandez alonso (vocal)<\/li>\n<li> Fernandez tome Mar\u00eda  paz (vocal)<\/li>\n<li> Rey de vi\u00f1asa rodr\u00edguez Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Rodriguez M. Luisa La hipertrofia ventricular izquierda es una respuesta adaptiva del coraz\u00f3n a una sobrepresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,156,1323],"tags":[23437,23439,183923,898,7408,183924],"class_list":["post-88042","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-patologia","category-patologia-experimental","tag-carmen-delgado-canencia","tag-fernandez-tome-maria-paz","tag-Martinez-rodriguez-m-luisa","tag-pedro-lorenzo-fernandez","tag-rey-de-vinasa-rodriguez-jose-luis","tag-soledad-fernandez-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88042"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88042\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}