{"id":88086,"date":"2018-03-10T00:12:59","date_gmt":"2018-03-10T00:12:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anfotericina-b-determinacion-en-diversos-fluidos-biologicos-por-cromatografa%c2%ada-la%c2%adquida-aplicacion-a-estudios-farmacocineticos-y-de-estabilidad-qua%c2%admica\/"},"modified":"2018-03-10T00:12:59","modified_gmt":"2018-03-10T00:12:59","slug":"anfotericina-b-determinacion-en-diversos-fluidos-biologicos-por-cromatografa%c2%ada-la%c2%adquida-aplicacion-a-estudios-farmacocineticos-y-de-estabilidad-qua%c2%admica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/anfotericina-b-determinacion-en-diversos-fluidos-biologicos-por-cromatografa%c2%ada-la%c2%adquida-aplicacion-a-estudios-farmacocineticos-y-de-estabilidad-qua%c2%admica\/","title":{"rendered":"Anfotericina b: determinaci\u00f3n en diversos fluidos biol\u00f3gicos por cromatograf\u00edal\u00edquida. aplicaci\u00f3n a estudios farmacocin\u00e9ticos y de estabilidad qu\u00edmica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa M. L\u00f3pez Galera <\/strong><\/h2>\n<p>La incidencia de infecciones f\u00fangicas ha aumentado en los \u00faltimos a\u00f1os debido al incremento de situaciones cl\u00ednicas que comportan alteraciones en los mecanismos de defensa del organismo tales como neoplasias, pacientes portadores de un trasplante y tratados con f\u00e1rmacos inmunosupresores o s\u00edndrome de la inmunodeficiencia adquirida (sida), entre otros.  la anfotericina b (anb), comercializada en 1956, contin\u00faa siendo el f\u00e1rmaco de elecci\u00f3n para el tratamiento de las micosis sist\u00e9micas, aunque su utilizaci\u00f3n no est\u00e1 exenta de toxicidad. Las nuevas formulaciones lip\u00eddicas de anb comercializadas a partir d e1995, han supuesto en la pr\u00e1ctica cl\u00ednica una mejora en la optimizaci\u00f3n de la terapia ya que su administraci\u00f3n ha demostrado estar asociada a una menor incidencia de reacciones adversas. antes de la comercializaci\u00f3n de \u00e9stas, ha sido frecuente la utilizaci\u00f3n de anb vehiculada en un exipiente de caracter\u00edsticas lip\u00f3filas como es el intralipid 20%, preparada como formulaci\u00f3n magistral en el momento de la infusi\u00f3n endovenosa por no disponer de estudios de estabilidad. La aspergilosis pulmonar invasiva es una infecci\u00f3n f\u00fangica que puede aparecer como complicaci\u00f3n en la cl\u00ednica de pacientes inmunodeprimidos cuya profilaxis con la formulaci\u00f3n de anb en soluci\u00f3n acuosa para inhalaci\u00f3n, ha demostrado una buena eficacia cl\u00ednica exenta de los efectos adversos y toxicidad asociados a la administraci\u00f3n endovenosa. En esta memoria se presentan los resultados de tres trabajos en formato de publicaciones en los cuales se estadariza y valida un m\u00e9todo para la determinaci\u00f3n de anb en muestras biol\u00f3gicas (suero, secreciones respiratorias) y muestras lip\u00eddicas con aplicaci\u00f3n a estudios farmacocin\u00e9ticos y de estabilidad qu\u00edmica de anb cuando \u00e9sta se administra en diferentes formas famac\u00e9uticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anfotericina b: determinaci\u00f3n en diversos fluidos biol\u00f3gicos por cromatograf\u00edal\u00edquida. aplicaci\u00f3n a estudios farmacocin\u00e9ticos y de estabilidad qu\u00edmica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anfotericina b: determinaci\u00f3n en diversos fluidos biol\u00f3gicos por cromatograf\u00edal\u00edquida. aplicaci\u00f3n a estudios farmacocin\u00e9ticos y de estabilidad qu\u00edmica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa M. L\u00f3pez Galera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Pascual Mostaza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Gonz\u00e1lez sastre <\/li>\n<li>Antonio Ju\u00e1rez gim\u00e9nez (vocal)<\/li>\n<li>Alberto Pahissa berga (vocal)<\/li>\n<li>Santiago Grau cerrato (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa M. L\u00f3pez Galera La incidencia de infecciones f\u00fangicas ha aumentado en los \u00faltimos a\u00f1os debido al [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,561,17],"tags":[1089,1243,64571,13646,183993,183994],"class_list":["post-88086","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-farmacologia-molecular","category-quimica","tag-alberto-pahissa-berga","tag-antonio-juarez-gimenez","tag-carlos-pascual-mostaza","tag-francesc-gonzalez-sastre","tag-rosa-m-lopez-galera","tag-santiago-grau-cerrato"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88086"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88086\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}