{"id":88102,"date":"2018-03-10T00:12:59","date_gmt":"2018-03-10T00:12:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/coagulacion-intravascular-diseminada-inducida-por-endotoxina-en-conejos-tratamiento-con-hirudina-t-pa-hirudina-t-t-pa-y-anticuerpo-monoclonal-anti-pai-1\/"},"modified":"2018-03-10T00:12:59","modified_gmt":"2018-03-10T00:12:59","slug":"coagulacion-intravascular-diseminada-inducida-por-endotoxina-en-conejos-tratamiento-con-hirudina-t-pa-hirudina-t-t-pa-y-anticuerpo-monoclonal-anti-pai-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/coagulacion-intravascular-diseminada-inducida-por-endotoxina-en-conejos-tratamiento-con-hirudina-t-pa-hirudina-t-t-pa-y-anticuerpo-monoclonal-anti-pai-1\/","title":{"rendered":"Coagulacion intravascular diseminada inducida por endotoxina en conejos: tratamiento con hirudina, t-pa, hirudina + t -t-pa y anticuerpo monoclonal anti-pai-1."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mu\u00f1oz Turrillas M. Carmen <\/strong><\/h2>\n<p>La coagulaci\u00f3n intravascular diseminada (cid) es un s\u00edndrome caracterizado por la activaci\u00f3n de la coagulaci\u00f3n conformaci\u00f3n de fibrina en la microvasculatura con el consiguiente da\u00f1o multiorg\u00e1nico. La sepsis es la enfermedad que m\u00e1s frecuentemente cursa con cid.  analizamos en un modelo experimental de cid inducida por endotoxina en conejos, en el que se estudian diversos par\u00e1metros de la hemostasia, los dep\u00f3sitos de fibrina renales y la mortalidad a las 24 horas, el efecto de dos grupos de tratamiento: 1)un antitromb\u00f3tico, la hirudina y un profibrinol\u00edtico, el t-pa, administrados de forma individual y combinada;2) un tratamiento contra la inhibici\u00f3n de la fibrinolosis: anticuerpos monoclonales contra el pai-1 (nov25 sintetizado en nuestro propio laboratorio y ma33b8, cedido por el dr declerck de la universidad de lovaina).  en el estudio \u00abhirudina \/t-pa\u00bb, la administraci\u00f3n de r-hirudina sola ofreci\u00f3 buenos resultados pero los mejores se obtuvieron con la combinaci\u00f3n de hirudina y t-pa en cuanto a la reducci\u00f3n del consumo de plaquetas, proteina c, a la reducci\u00f3n del incremento de pai-1 de los depositos de fibrina. la mortalidad a las 24 horas descendi\u00f3 desde el 70% en el grupo control endotoxina a 40%,10% y 0% en los grupos \u00abt-pa\u00bb, \u00abhirudina\u00bb e \u00abhirudina +t-pa\u00bb, respectivamente.  en el estudio anti-pai-1, tanto nov25 como ma33b8 redujeron significativamente el incremento de pai-1 plasm\u00e1tico, aunque el segundo lo hizo con m\u00e1s intensidad. solo ma33b8 redujo significativamente los dep\u00f3sitos de fibrina y esta reducci\u00f3n mostro una correlaci\u00f3n positiva con los niveles de pai-1 plasm\u00e1ticos y se acompa\u00f1\u00f3 de una reducci\u00f3n del marcaje de pai local a nivel renal, estudio realizado mediante imunohistoqu\u00edmica. No obstante, no se obtuvieron resultados satisfactorios en cuanto a la reducci\u00f3n de la mortalidad, lo que nos lleva a pensar que \u00e9sta no solo se debe el desequilibrio hemost\u00e1tico sino tambi\u00e9n a los mecanismos i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Coagulacion intravascular diseminada inducida por endotoxina en conejos: tratamiento con hirudina, t-pa, hirudina + t -t-pa y anticuerpo monoclonal anti-pai-1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Coagulacion intravascular diseminada inducida por endotoxina en conejos: tratamiento con hirudina, t-pa, hirudina + t -t-pa y anticuerpo monoclonal anti-pai-1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mu\u00f1oz Turrillas M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Rocha Hernando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas fernando San Miguel izquierdo <\/li>\n<li>Mar\u00eda Moraleda jose (vocal)<\/li>\n<li>Javier Diez Martinez (vocal)<\/li>\n<li>pablo Monedero rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mu\u00f1oz Turrillas M. Carmen La coagulaci\u00f3n intravascular diseminada (cid) es un s\u00edndrome caracterizado por la activaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,41163,218,195,139,17749,156],"tags":[8788,11773,9596,84657,184022,71033],"class_list":["post-88102","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-endotoxinas","category-hematologia","category-hemopatologia","category-medicina-interna","category-navarra","category-patologia","tag-eduardo-rocha-hernando","tag-javier-diez-Martinez","tag-jesus-fernando-san-miguel-izquierdo","tag-maria-moraleda-jose","tag-munoz-turrillas-m-carmen","tag-pablo-monedero-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88102"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88102\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}