{"id":88109,"date":"2018-03-10T00:13:03","date_gmt":"2018-03-10T00:13:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-diagnostico-y-pronostico-de-las-citoqueratinas-tpa-tps-y-cyfra-21-1-en-suero-en-el-carcinoma-de-celulas-transicionales-de-vejiga\/"},"modified":"2018-03-10T00:13:03","modified_gmt":"2018-03-10T00:13:03","slug":"valor-diagnostico-y-pronostico-de-las-citoqueratinas-tpa-tps-y-cyfra-21-1-en-suero-en-el-carcinoma-de-celulas-transicionales-de-vejiga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-diagnostico-y-pronostico-de-las-citoqueratinas-tpa-tps-y-cyfra-21-1-en-suero-en-el-carcinoma-de-celulas-transicionales-de-vejiga\/","title":{"rendered":"Valor diagn\u00f3stico y pron\u00f3stico de las citoqueratinas (tpa, tps y cyfra 21-1) en suero en el carcinoma de c\u00e9lulas transicionales de vejiga"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana L\u00f3pez Celada <\/strong><\/h2>\n<p>Los objetivos del presente estudio son estudiar el valor de las citoqueratinas en el diagn\u00f3stico y para la predicci\u00f3n de recidivas o progresi\u00f3n del carcinoma de c\u00e9lulas transicionales de vejiga y determinar la rentabilidad diagn\u00f3stica de las mismas.  para ello se ha extraido suero de 558 individuos repartidos en cuatro grupos: grupo tumoral (t), con antecedentes pero sin evidencia actual de tumor (set), con patolog\u00eda urol\u00f3gica benigna (pub) y por \u00faltimo un grupo de controles sanos (c) y se han determinado los valores de tpa, tpa-m, tps y cyfra 21-1 relacionando dichas citoqueratinas con los factores pron\u00f3sticos conocidos en el c\u00e1ncer de c\u00e9lulas transicionales.  en general existe una elevaci\u00f3n de todas las citoqueratinas en el grupo tumoral, con diferencias significativas con respecto al resto de grupos, siendo esta elevaci\u00f3n mayor en los casos tumorales m\u00e1s avanzados. Se han encontrado una relaci\u00f3n significativa con la mortalidad de los valores de tpa, tpa-m y tps superiores al punto de corte designado para cada uno de ellos, aunque \u00fanicamente el nivel s\u00e9rico inicial de tps tiene valor pron\u00f3stico independiente. Con respecto a la aparici\u00f3n de recidicas, ninguna de las citoqueratinas tiene valor cuando es determinada inicialmente. En el grupo sin evidencia de tumor, las citoqueratinas no se han relacionado con la mortalidad.S\u00ed se ha encontrado, en cambio, relaci\u00f3n de la concentraci\u00f3n s\u00e9rica inicial de tpa con la aparici\u00f3n de recidivas, aunque no tiene valor pron\u00f3stico independiente. La prueba que nos proporciona mayor rendimiento diang\u00f3stico es la determinaci\u00f3n de tpa mediante anticuerpos monoclonales.  concluimos que, aunque se pueden utilizar las citoqueratinas s\u00e9ricas para diferenciar los pacientes con tumor de los que no lo presentan y para distinguir entre enfermedad inicial o avanzada, debido a su baja sensibilidad y especificidad, no se deben de utilizar aisladamente para establecer un diagn\u00f3stico defin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor diagn\u00f3stico y pron\u00f3stico de las citoqueratinas (tpa, tps y cyfra 21-1) en suero en el carcinoma de c\u00e9lulas transicionales de vejiga<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor diagn\u00f3stico y pron\u00f3stico de las citoqueratinas (tpa, tps y cyfra 21-1) en suero en el carcinoma de c\u00e9lulas transicionales de vejiga <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana L\u00f3pez Celada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Calpena Rico<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felix Grases freixedas <\/li>\n<li>Juan Alcover Garc\u00eda (vocal)<\/li>\n<li>Manuel Gil salom (vocal)<\/li>\n<li>violeta Menendez l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana L\u00f3pez Celada Los objetivos del presente estudio son estudiar el valor de las citoqueratinas en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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