{"id":88114,"date":"2018-03-10T00:13:03","date_gmt":"2018-03-10T00:13:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-melatonina-en-el-crecimiento-y-diferenciacion-de-celulas-ht-29-de-cancer-de-colon\/"},"modified":"2018-03-10T00:13:03","modified_gmt":"2018-03-10T00:13:03","slug":"papel-de-la-melatonina-en-el-crecimiento-y-diferenciacion-de-celulas-ht-29-de-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-melatonina-en-el-crecimiento-y-diferenciacion-de-celulas-ht-29-de-cancer-de-colon\/","title":{"rendered":"Papel de la melatonina en el crecimiento y diferenciacion de celulas ht-29 de cancer de colon."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Garcia Navarro <\/strong><\/h2>\n<p>Se estudia el efecto de la melatonina sobre la proliferaci\u00f3n celular de la l\u00ednea c\u00e9lular ht-29 procedente de un adenocarcinoma de colon humano. las c\u00e9lulas en fase exponencial del crecimiento fueron expuestas concentraciones de melatonina en el rango 10nm a 4mm durante 48 horas. La proliferaci\u00f3n se medi\u00f3 de forma indirecta mediante cuantificaci\u00f3n de la incorporaci\u00f3nde timidina marcada contritio en el proceso de s\u00edntesis del \u00e1cido desoxirribonucleico.  se obtuvo inhibici\u00f3n de la proliferaci\u00f3ncelular del 25,7%, 56,4% y 94,6% conlas concentraciones 1mm, 2mm y 4mm respectivamente. Para investigar el papel de los receptores de membrana y nuclear de la melatonina en este efecto se realizaron experimentos similares tras exponer las c\u00e9lular a agonistas de los diferentes tipos de receptores de membrana (2-i-melatonina, 2-i-butanoil-5-metoxitriptamina y gr 135,531), a antagonistas de los distintos subtipos (luzindol, 4-p-pdot y prazos\u00edn) en presencia de melatonina y el agosnista del receptor nuclear de melatonina cgp 52608, as\u00ed como a este \u00faltimo junto conmelatonina. Tambi\u00e9n se midi\u00f3 la incorporaci\u00f3n de timidina tras el tratamietnod e c\u00e9lulas con melatonina tras bloquear las prote\u00ednas gi\/o contoxina pert\u00fastica. Los agonistas de los receptores de membrna fueron capaces de inhibir la proliferaci\u00f3n celular de una forma igual o m\u00e1s potente que la melatonina. Sin embargo el efecto antiporliferativo de la melatonina no fue bloqueado por los antangonistas de ninguno de los diferentes subtipos de receptor ni tras bloquear las prote\u00edna g asociadas a los recptores de membrana de la melatonina lo cual indica que los receptores de membrana no participan en el efecto antiproliferativo de la melatonina. Por otra parte la incorporaci\u00f3nd e timidina disminuy\u00f3 con el agoninsta del receptor nuclear de la melantonina con una ic50 pr\u00f3sima a la melatonina y la incubaci\u00f3n conmelatonina + cgp 52608 produjo una potenciaci\u00f3n significativa del ef<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la melatonina en el crecimiento y diferenciacion de celulas ht-29 de cancer de colon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la melatonina en el crecimiento y diferenciacion de celulas ht-29 de cancer de colon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Garcia Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dario Acu\u00f1a Castroviejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Ros die <\/li>\n<li>joaquin Garcia garcia (vocal)<\/li>\n<li> Garica gil Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Ana Mar\u00eda Coto montes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Garcia Navarro Se estudia el efecto de la melatonina sobre la proliferaci\u00f3n celular de la l\u00ednea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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