{"id":88115,"date":"2018-03-10T00:13:03","date_gmt":"2018-03-10T00:13:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/participacion-de-los-receptores-de-gastrina-colecistoquinina-y-su-interaccion-con-la-melatonina-en-el-crecimiento-y-diferenciacion-de-celulas-ht-29-de-cancer-de-colon\/"},"modified":"2018-03-10T00:13:03","modified_gmt":"2018-03-10T00:13:03","slug":"participacion-de-los-receptores-de-gastrina-colecistoquinina-y-su-interaccion-con-la-melatonina-en-el-crecimiento-y-diferenciacion-de-celulas-ht-29-de-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/participacion-de-los-receptores-de-gastrina-colecistoquinina-y-su-interaccion-con-la-melatonina-en-el-crecimiento-y-diferenciacion-de-celulas-ht-29-de-cancer-de-colon\/","title":{"rendered":"Participacion de los receptores de gastrina\/colecistoquinina, y su interaccion con la melatonina en el crecimiento y diferenciacion de celulas ht-29 de cancer de colon."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Cristina Gonzalez Puga <\/strong><\/h2>\n<p>Teniendo en cuenta que en muchos estudios se ha apreciado un efecto de la gastrina como estimulante de la proliferaci\u00f3n con c\u00e9lular de c\u00e1ncer colorrectal, que se hanidenrificado sitios de uni\u00f3n para esta hormona en dichas c\u00e9lulas, y en vista de la estrecha relaci\u00f3nexistente entre gastrina\/ colecistoquimina (cck) y sus recptores, nos hemos planteado estudiar el papel de la gasstrina y de la cck en la prolferaci\u00f3n de la l\u00ednea celular ht-29, correspondiente a un adenocarcionoma de colon humano.  tambi\u00e9n hemos investigado el efecto inhibidor del crecimeinto celular de diversos antagonistas espec\u00edficos de los receptores de ccdk, (cck-a y cck-b), y el efecto de los antagonistas espec\u00edficos de los receptores cck-a sobre la producci\u00f3n de \u00f3xido n\u00edtrico por estas c\u00e9lulas, mediante la determinaci\u00f3n de nitritos. Adem\u00e1s, puesto que la melatonina tiene un importante papel oncost\u00e1tico endistintos tipos de c\u00e1nceres, nos hemos palanteado comprobar si esta hormona inhibe la prolferaci\u00f3n de esta l\u00ednea celular, y determinar si existe alguna interacci\u00f3n entre melatonina y los distinos antagonistas de los receptores cck para inhibir esta proliferaci\u00f3n. Por \u00faltimo, hemos estudiado si la inhibici\u00f3n de la proliferaci\u00f3nde c\u00e9lular ht-29 inducida por estos productos se debe a una estimulaci\u00f3n de los procesos de apoptosis y\/o necrosis.  los productos empleados en este estudio son:  &#8211; gastrina (agonista cck-b) y cck-8s (agonista cck-a)  &#8211; proglumida (antagonista cck-a y cck-b)  &#8211; lorglumida y l 364,718 o devazepide (antagonistas espec\u00edficos cck-a)  &#8211; l365,718 y pd 135,158 (antagonistas espec\u00edficos cck-b)  &#8211; melatonina.  hemos comprobado que tras el tratamientod e la l\u00ednea celular ht-29 congastrina y con los antagonistas espec\u00edficos del receptor cck-b no se aprecia ninguna alteraci\u00f3n en la proliferaci\u00f3n c\u00e9lular. Sin embargo, el cultivo de las mismas con cck-8s ocasiona un incremento significativo de la proliferaci\u00f3n celular,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Participacion de los receptores de gastrina\/colecistoquinina, y su interaccion con la melatonina en el crecimiento y diferenciacion de celulas ht-29 de cancer de colon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Participacion de los receptores de gastrina\/colecistoquinina, y su interaccion con la melatonina en el crecimiento y diferenciacion de celulas ht-29 de cancer de colon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Cristina Gonzalez Puga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dario Acu\u00f1a Castroviejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Ros die <\/li>\n<li>joaquin Garcia garcia (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Garcia gil (vocal)<\/li>\n<li>Ana Mar\u00eda Coto montes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Cristina Gonzalez Puga Teniendo en cuenta que en muchos estudios se ha apreciado un efecto de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,141,387,347],"tags":[25292,3394,1555,75025,4296,184039],"class_list":["post-88115","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-cirugia","category-cirugia-abdominal","category-oncologia-clinica","tag-ana-maria-coto-montes","tag-dario-acuna-castroviejo","tag-eduardo-ros-die","tag-joaquin-garcia-garcia","tag-jose-maria-garcia-gil","tag-maria-cristina-gonzalez-puga"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88115"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88115\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}