{"id":88116,"date":"2018-03-10T00:13:03","date_gmt":"2018-03-10T00:13:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-inmediatos-y-a-largo-plazo-inducidos-por-la-administracion-intracerebral-o-sistemica-de-34-metilenodioximentanfetamina-mdma\/"},"modified":"2018-03-10T00:13:03","modified_gmt":"2018-03-10T00:13:03","slug":"efectos-inmediatos-y-a-largo-plazo-inducidos-por-la-administracion-intracerebral-o-sistemica-de-34-metilenodioximentanfetamina-mdma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-inmediatos-y-a-largo-plazo-inducidos-por-la-administracion-intracerebral-o-sistemica-de-34-metilenodioximentanfetamina-mdma\/","title":{"rendered":"Efectos inmediatos y a largo plazo inducidos por la administracion intracerebral o sistemica de 3,4-metilenodioximentanfetamina (mdma)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Blanca Esteban Barrios <\/strong><\/h2>\n<p>La3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) produce una degeneraci\u00f3n selectiva de los terminales nerviosos serotonin\u00e9rgicos en el cerbro de roedores y primates cuando se adminsitra por v\u00eda sist\u00e9matica (green et al., 1995).  diversas evidencias experimentales indican que los radicales hidroxilo est\u00e1n implicados en el procesoneurodegenerativo (colado et al., 1997). estas especies reactivas de ox\u00edgeno podr\u00edan proceder del metabolismo de la mdma, la cual es metabolizada a compuestos con estructura catecol y quinona capaces de originar la formaci\u00f3n de radicales libres (hiramatsu et al., 1990). Hasta ahora los compuestos conocidos derivados del metabolismo de la mdma tienen estructura hidrof\u00edlica, y por tanto, atravesar\u00edan la barrera hamatoencef\u00e1lica con dificultada.  en esta tesis doctoral, utilizando  la t\u00e9cnica de la microdi\u00e1lisis intracerebral in vivo, se han estudiado los efectos agudos y a largo plazo producidos por la administraci\u00f3n intracerebral mdma a concentraciones iguales o superiores a la al canzada por la droga en el cerebro cuando se adminsitra por v\u00eda sist\u00e9matica (intraperitoneal) en ratas dark agouti.  los resultados obtenidos indican que la administraci\u00f3n intrahipocampla de mdma,no produce, a largo plazo, evidencia de respuesta neurot\u00f3xica, mientras que la administraci\u00f3n sist\u00e9matica produce d\u00e9ficits seroton\u00e9rgicos pronunciados asociados con neurodegeneraci\u00f3n.  no obstante, la administraci\u00f3n de mdma en el hipocampo produce efectos agudos sobre la neurotransmisi\u00f3n serotonin\u00e9rgica y dopamin\u00e9rgica que son similares a los observados tras su administraci\u00f3n sist\u00e9mica. Considerados en conjunto, estos resultados sugieren que la neurodegeneraci\u00f3n de mdma se debe a alg\u00fan  compuesto procedente del metabolismo de la droga a nivel perif\u00e9rico e indican que los efectos agudos de la mdma son independientes de los cambios que se obsevan a largo plazo sobre la funci\u00f3n serotonin\u00e9rgica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos inmediatos y a largo plazo inducidos por la administracion intracerebral o sistemica de 3,4-metilenodioximentanfetamina (mdma).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos inmediatos y a largo plazo inducidos por la administracion intracerebral o sistemica de 3,4-metilenodioximentanfetamina (mdma). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Blanca Esteban Barrios <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Colado Megia M. Isabel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fernandez <\/li>\n<li> Aguacil merino Luis Fernando (vocal)<\/li>\n<li> Oset gasque Mar\u00eda  Jes\u00fas (vocal)<\/li>\n<li> Rey de vi\u00f1asa rodr\u00edguez Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Blanca Esteban Barrios La3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) produce una degeneraci\u00f3n selectiva de los terminales nerviosos serotonin\u00e9rgicos en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957],"tags":[184041,184040,66544,184042,898,7408],"class_list":["post-88116","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","tag-aguacil-merino-luis-fernando","tag-blanca-esteban-barrios","tag-colado-megia-m-isabel","tag-oset-gasque-maria-jesus","tag-pedro-lorenzo-fernandez","tag-rey-de-vinasa-rodriguez-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88116"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88116\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}