{"id":88149,"date":"2018-03-10T00:13:03","date_gmt":"2018-03-10T00:13:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-contenido-de-colesterol-y-disponibilidad-de-mevalonato-sobre-la-expresion-de-proteinas-g\/"},"modified":"2018-03-10T00:13:03","modified_gmt":"2018-03-10T00:13:03","slug":"efecto-del-contenido-de-colesterol-y-disponibilidad-de-mevalonato-sobre-la-expresion-de-proteinas-g","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-del-contenido-de-colesterol-y-disponibilidad-de-mevalonato-sobre-la-expresion-de-proteinas-g\/","title":{"rendered":"Efecto del contenido de colesterol y disponibilidad de mevalonato sobre la expresi\u00f3n de proteinas g"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Italo Alfonso Chiffelle Gomez <\/strong><\/h2>\n<p>Para ver los efectos de las variaciones en el contenido de colesterol celular y mevalonato sobre la expresi\u00f3n de la prote\u00edna ras y dim\u00e9ro betagamma en c\u00e9lulas gh4c1, incubamos estas c\u00e9lulas por diferentes per\u00edodos de tiempo en suero libre de lipoprote\u00ednas, lpds (situaci\u00f3n de alta s\u00edntesis de mevalonato), lpds suplementado con 25 hc y colesterol (baja s\u00edntesis de mevalonato) con y sin mevalonato, y determinamos la cantidad de ras en la fracci\u00f3n en membranas o en el homogenado total.  la presencia de mevalonato es requerido imprescindible para que ras se procese y se ancle a la membrana plasm\u00e1tica. De hecho, el aumento del mevalonato produjo un aumento de la localizaci\u00f3n de ras en la membrana y su disminuci\u00f3n la redujo. Este efecto parece estar relacionado con la disponibilidad de restos farnesilos. Adem\u00e1s del conocido papel del mevalonato en el anclaje ras en la membrana plasm\u00e1tica, hemos encontrado que, al menos en nuestras c\u00e9lulas, el mevalonato tambi\u00e9n regula la expresi\u00f3n de ras, dado que tanto el mrna de ras como los niveles de prote\u00edna se inhiben en funci\u00f3n la dosis de mevalonato.  el colesterol tambi\u00e9n disminuy\u00f3 de forma paralela los niveles de ras, y los de su mensajerjo de forma dependiente del tiempo. La adici\u00f3n de mevalonato no modific\u00f3 el fecto del colesterol, aunque lo adelant\u00f3 en el tiempo, lo que parece indicar que el colesterol act\u00faa por un mecanismo similar al mevalonato, gracias a su capacidad de modificar la cantidad y el metabolismo del mismo.  nuestros datos parecen indicar que la expresi\u00f3n de ras se inhibe por la acumulaci\u00f3n de alg\u00fan derivado no esteroideo del mevalonato. En primer lugar, la expresi\u00f3n de ras disminuy\u00f3 tanto si se aumenta la s\u00edntesis end\u00f3gena de mevalonato (c\u00e9lulas en presencia de lpds) como si se aumenta la proporci\u00f3n de mevalonato que acumula productos no esteroideos (adici\u00f3n de colesterol y 25-hidroxicolesterol). Por otra parte, la supresi\u00f3n total de la s\u00edntes<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del contenido de colesterol y disponibilidad de mevalonato sobre la expresi\u00f3n de proteinas g<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del contenido de colesterol y disponibilidad de mevalonato sobre la expresi\u00f3n de proteinas g <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Italo Alfonso Chiffelle Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Josefa Toro Nozal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  L\u00f3pez-fando castro Juan  jos\u00e9 <\/li>\n<li>Juan  Miguel Ruiz albusac (vocal)<\/li>\n<li>Manuel Ros perez (vocal)<\/li>\n<li>diego G\u00f3mez coronado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Italo Alfonso Chiffelle Gomez Para ver los efectos de las variaciones en el contenido de colesterol celular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,35,2135,817],"tags":[184095,184094,88158,23014,7154,14322],"class_list":["post-88149","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-de-la-vida","category-fisiologia-endocrina","category-fisiologia-humana","tag-diego-gomez-coronado","tag-italo-alfonso-chiffelle-gomez","tag-juan-miguel-ruiz-albusac","tag-lopez-fando-castro-juan-jose","tag-manuel-ros-perez","tag-ma-josefa-toro-nozal"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88149"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88149\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}