{"id":88166,"date":"2018-03-10T00:13:03","date_gmt":"2018-03-10T00:13:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anisakis-y-alergia\/"},"modified":"2018-03-10T00:13:03","modified_gmt":"2018-03-10T00:13:03","slug":"anisakis-y-alergia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/anisakis-y-alergia\/","title":{"rendered":"Anisakis y alergia"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lorenzo Iglesias Sonia M. <\/strong><\/h2>\n<p>En los \u00faltimos cinco a\u00f1os se han descrito en nuestro pa\u00eds numerosos casos de alergia debida al nematodo anisakis simplex. Con el fin de mejorar las t\u00e9cnicas de diagn\u00f3stico serol\u00f3gico de la anisaquiosis y de la alergia inducida por anisakis, en el presente trabajo nos propusimos desarrollar un sistema de serodiagn\u00f3stico fiable basado en la utilizaci\u00f3n de los anticuerpos monoclonales (acms)ua2 y ua3 espec\u00edficos d e a. Simplex. Tras analizar, mediante ensayos elisa-captura basados en los acms ua2 y ua3, los perfiles isot\u00edpicos que se inducen con mayor frecuencia durante la anisaquiosis y la alergia debida a anisakis, procedimos a realizar estudios de especificidad utilizando como control negativo una serie de sueros procedentes de poblaciones que nunca hab\u00edan estado en contacto con anisakis. Mediante estos estudios, pudimos comprobar que el ensayo elisa-ua3 que utiliza como preparaci\u00f3n antig\u00e9nica ant\u00edgeno o-desglucosilado de anisakis, pod\u00eda ser considerado como un m\u00e9todo de diagn\u00f3stico \u00f3ptimo, puesto que presentaba un 100% de sensibilidad y de especificidad en la determinaci\u00f3n de anticuerpos ige anti-anisakis. Adem\u00e1s, pudimos comprobar que los oligosac\u00e1ridos de tipo o-glucano y otras mol\u00e9culas como las biotinilenzimas que se hallan muy conservadas evolutivamente pueden ser fuente de reactividad cruzada en sistemas de diagn\u00f3stico de la ansiaquiosis\/alergia a anisakis que utilicen como ant\u00edgeno,extractos totales del par\u00e1sito. En este sentido, al realizar un estudio comparativo entre nuestro ensayo elisa-ua3 y dos t\u00e9cnicos serol\u00f3gicas, inmunocap e inmunotransferencia, utilizadas a nivel de laboratorio para determinar anticuerpos ige frente a anisakis y que utilizan un extracto completo de nematodo, pudimos comprobar que estas t\u00e9cnicas presentaban una baja especificidad, que no hab\u00eda sido descrita hasta el momento, mientras que el ensayo elisa-ua3 presentaba un 100% de especificidad, que no hab\u00eda sido descrita hasta e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anisakis y alergia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anisakis y alergia <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lorenzo Iglesias Sonia M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Florencio Mart\u00ednez Ubeira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel l. Sanmart\u00edn dur\u00e1n <\/li>\n<li>concepci\u00f3n L\u00f3pez serrano (vocal)<\/li>\n<li>Santiago Hern\u00e1ndez rodr\u00edguez (vocal)<\/li>\n<li>ignacio Javier Ansotegui zubeldia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorenzo Iglesias Sonia M. En los \u00faltimos cinco a\u00f1os se han descrito en nuestro pa\u00eds numerosos casos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1957,9,516,156,977],"tags":[29950,2683,51362,184119,2729,3217],"class_list":["post-88166","post","type-post","status-publish","format-standard","hentry","category-alergias","category-ciencias-medicas","category-parasitologia-humana","category-patologia","category-santiago-de-compostela","tag-concepcion-lopez-serrano","tag-florencio-Martinez-ubeira","tag-ignacio-javier-ansotegui-zubeldia","tag-lorenzo-iglesias-sonia-m","tag-manuel-l-sanmartin-duran","tag-santiago-hernandez-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88166"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88166\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}