{"id":88181,"date":"2018-03-10T00:13:08","date_gmt":"2018-03-10T00:13:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interes-cla%c2%adnico-de-la-determinacion-del-porcentaje-psal-psat-en-el-diagnostico-diferencial-entre-hiperplasia-prostatica-benigna-y-cancer-de-prostata\/"},"modified":"2018-03-10T00:13:08","modified_gmt":"2018-03-10T00:13:08","slug":"interes-cla%c2%adnico-de-la-determinacion-del-porcentaje-psal-psat-en-el-diagnostico-diferencial-entre-hiperplasia-prostatica-benigna-y-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interes-cla%c2%adnico-de-la-determinacion-del-porcentaje-psal-psat-en-el-diagnostico-diferencial-entre-hiperplasia-prostatica-benigna-y-cancer-de-prostata\/","title":{"rendered":"\u00abinter\u00e9s cl\u00ednico de la determinaci\u00f3n del porcentaje psal\/psat en el diagnostico diferencial entre hiperplasia prost\u00e1tica benigna y c\u00e1ncer de pr\u00f3stata\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Rodriguez M\u00aa Isabel <\/strong><\/h2>\n<p>El c\u00e1ncer de pr\u00f3stata (cp) es una enfermedad con una incidencia creciente y en asturias ocupa el segundo lugar en frecuencia entre las neoplasias malignas en el hombre, tras la de pulm\u00f3n. La tasa espec\u00edfica por 100.000 habitantes es de 24,8%, lo que representa la segunda causa de muerte por c\u00e1ncer en el var\u00f3n. El ant\u00edgeno prost\u00e1tico espec\u00edfico (psa),glicoprote\u00edna de la familia de las kalicre\u00ednas tisulares humanas, es el marcador tumoral m\u00e1s empleado en el cp y es de gran utilidad en el pr\u00e1ctica cl\u00ednica diaria. su mayor inconveniente es su baja especificidad y alta tasa de falsos positivos ya que tambi\u00e9n se eleva en patolog\u00edas prost\u00e1ticas benignas. Adem\u00e1s, un 38-48% de los cp localizados tienen cifras de psa s\u00e9rico normales. Recientemente, se ha descubierto que el psa est\u00e1 presente en la sangre en tres formas:psa libre (psal),unido a la     1-antiquimotripsina(psa-act) y unido a la 2-macroglobulina (psa-amg), en concentraci\u00f3n variable seg\u00fan el estado de enfermedad de la gl\u00e1ndula prost\u00e1tica.  objetivos: analizar el comportamiento del psa,psal y porcentaje psa total(%psal\/psat) en hiperplasia prost\u00e1tica benigna (hpb) y cp, globalmente y en funci\u00f3n de ciertos par\u00e1metros (edad del paciente, volumen prost\u00e1tico,presencia de complicaciones cl\u00ednicas como congesti\u00f3n e inflamaci\u00f3n prost\u00e1tica y retenci\u00f3n urinaria, hallazgos del tacto rectal y estadio cl\u00ednico, grado de diferenciaci\u00f3n histol\u00f3gica y de gleason en el cp),comprobar si los resultados del %psal\/psat se ven influenciados por el ensayo empleado, determinar su utilidad en el diagn\u00f3stico diferencial de ambas patolog\u00edas y establecer un valor de aplicaci\u00f3n cl\u00ednica.  material-m\u00e9todos:se determinaron el psa y psal s\u00e9ricos en un grupo de individuos control (entre 14 y 57, seg\u00fan el ensayo considerado), en 132 pacientes con hpb y en 84 con cp. Los controles proced\u00edan del centro comunitario de transfusiones del principado de asturias y el resto de la consulta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abinter\u00e9s cl\u00ednico de la determinaci\u00f3n del porcentaje psal\/psat en el diagnostico diferencial entre hiperplasia prost\u00e1tica benigna y c\u00e1ncer de pr\u00f3stata\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abinter\u00e9s cl\u00ednico de la determinaci\u00f3n del porcentaje psal\/psat en el diagnostico diferencial entre hiperplasia prost\u00e1tica benigna y c\u00e1ncer de pr\u00f3stata\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Rodriguez M\u00aa Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Abascal Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pablo Carretero gonz\u00e1lez <\/li>\n<li>Manuel S\u00e1nchez chapado (vocal)<\/li>\n<li> Arribas castillo Jos\u00e9 Manuel (vocal)<\/li>\n<li>agustin Herrero zapatero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Rodriguez M\u00aa Isabel El c\u00e1ncer de pr\u00f3stata (cp) es una enfermedad con una incidencia creciente y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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