{"id":88205,"date":"2018-03-10T00:13:08","date_gmt":"2018-03-10T00:13:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-colinergica-de-las-sinapsis-glutamatergicas-en-neuronas-piramidales-de-ca1\/"},"modified":"2018-03-10T00:13:08","modified_gmt":"2018-03-10T00:13:08","slug":"modulacion-colinergica-de-las-sinapsis-glutamatergicas-en-neuronas-piramidales-de-ca1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-colinergica-de-las-sinapsis-glutamatergicas-en-neuronas-piramidales-de-ca1\/","title":{"rendered":"Modulacion colinergica de las sinapsis glutamatergicas en neuronas piramidales de ca1."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Fernadez De Sevilla Garcia <\/strong><\/h2>\n<p>La interacci\u00f3n colin\u00e9rgica con la transmisi\u00f3n glutamat\u00e9rgica puede influenciar ciertas formas de plasticidad sin\u00e1ptica que se piensa subyacen a los procesos de memoria y aprendizaje. En el hipocampo, las sinapsis glutamat\u00e9rgicas mejor estudiadas son las formadas por los axones colaterales de las neuronas piramidales de ca3(colaterales de schaffer, cs) y las neuronas piramidales de la region de ca1. Estas sinapsis son glutamat\u00e9rgicas y su corriente sin\u00e1ptica presenta dos componentes, el componente no-nmda, debido a la activaci\u00f3n de los receptores ionotr\u00f3picos de glutamato sensibles a ampa y kainato (no-nmdars) y el componente nmda, debido a la activaci\u00f3n de los receptores ionotr\u00f3picos de glutamato sensibles a nmda (nmdars). Hemos analizado la inhibici\u00f3n de la transmisi\u00f3n sin\u00e1ptica glutamat\u00e9rgicas inducida por agonistas colinergicos en celulas piramidales de ca1. Se registraron las corrientes de membrana con la tecnica de \u00abpatch\u00bb en rodajas de hipocampo. las corrientes postsin\u00e1pticas excitadoras (espcs) fueron evocadas po estimulaci\u00f3n de la cs. La sinapsis inhibitorias fueron bloqueadas mediante superfusi\u00f3n de picrotoxina 50 um). Los componentes mda y no-nmda de las epscs se aislaron farmacol\u00f3gicamente (20 um cnqx y 50 um apv, respectivamente). La aplicaci\u00f3n del agonista colin\u00e9rgico carbamilcolina (cch) en superfusi\u00f3n (5 um) indujo una pronunciada reducci\u00f3n del componente no-mmda de las epscs (86%), mientras que el componente nmda fue menos afectado (47%). Esta inhibici\u00f3n se vio acompa\u00f1ada de un aumento de la facilitaci\u00f3n por pares de pulsos sin cambio de las corrientes evocadas por microiontoforesis de glutamato indicando que el efecto de cch es presin\u00e1ptico. Adem\u00e1s los efectos de cch fueron reproducidos opor muscarina (5 um). Mediante protocolos de estimulaci\u00f3n minima registramos sinapsis funcionales y silenciosas. La superfusi\u00f3n de cch(5um) aument\u00f3 el numero de fallos en la transmisi\u00f3n sin\u00e1ptica de la sina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion colinergica de las sinapsis glutamatergicas en neuronas piramidales de ca1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion colinergica de las sinapsis glutamatergicas en neuronas piramidales de ca1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Fernadez De Sevilla Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Washington Bu\u00f1o Buceta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  De Andr\u00e9s de la calle isabel <\/li>\n<li>Juan Lerma gomez (vocal)<\/li>\n<li>Luis Carlos Barrio calvo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Fernadez De Sevilla Garcia La interacci\u00f3n colin\u00e9rgica con la transmisi\u00f3n glutamat\u00e9rgica puede influenciar ciertas formas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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