{"id":88224,"date":"2018-03-10T00:13:08","date_gmt":"2018-03-10T00:13:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-concentracion-sanguinea-de-hemoglobina-sobre-las-alteraciones-hemodinamicas-asociadas-a-la-hipertension-portal-relacion-con-el-oxido-nitrico\/"},"modified":"2018-03-10T00:13:08","modified_gmt":"2018-03-10T00:13:08","slug":"influencia-de-la-concentracion-sanguinea-de-hemoglobina-sobre-las-alteraciones-hemodinamicas-asociadas-a-la-hipertension-portal-relacion-con-el-oxido-nitrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-la-concentracion-sanguinea-de-hemoglobina-sobre-las-alteraciones-hemodinamicas-asociadas-a-la-hipertension-portal-relacion-con-el-oxido-nitrico\/","title":{"rendered":"Influencia de la concentracion sanguinea de hemoglobina sobre las alteraciones hemodinamicas asociadas a la hipertension portal. relacion con el oxido nitrico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josep Ignasi Elizalde Fernandez <\/strong><\/h2>\n<p>Puesto que la hemoglobina, in vitro, es capaz de modular la actividad biol\u00f3gica del oxido nitrico, se postul\u00f3 que, in vivo, cambios en la concentraci\u00f3n sanguinea de hemoglobina ser\u00edan capaces de modular el tono vascular en la hipertensi\u00f3n portal. Para contrastar esta hip\u00f3tesis, ratas con hipertensi\u00f3n portal o sometidas a una operaci\u00f3n ficticia se trataron con eritropoyetina o placebo y se evaluaron diversos par\u00e1metros hemodinamicos dos semanas m\u00e1s tarde. El aumento de masa eritrocitaria atenu\u00f3 el aumento en los flujos espl\u00e1cnicos y los descensos en la presi\u00f3n arterial y resistencias vasculares propios de este modelo experimental. Adem\u00e1s, tambien fren\u00f3 las respuestas frente a la administraci\u00f3n de nitroprusiato y l-name, lo que indica que el cuadro de vasodilataci\u00f3n espl\u00e1cnica asociado a la hipertensi\u00f3n portal puede atenuarse aumentando la concentraci\u00f3n sanguinea de hemoglobina, a trav\u00e9s de mecanismos que incluyen la inactivaci\u00f3n del no. Un estudio de cohortes revel\u00f3 que, en la cirrosis hep\u00e1tica humana, la coexistencia de anemia empeora la circulaci\u00f3n hiperdin\u00e1mica asociada a la hipertensi\u00f3n portal ya que, respecto a los casos sin anemia, los pacientes an\u00e9micos presentaron un gasto card\u00edaco m\u00e1s elevado y unas resistencias vasculares sitm\u00e9micas m\u00e1s bajas. El an\u00e1lisis de regresi\u00f3n log\u00edstica revel\u00f3, que adem\u00e1s de la edad, el sexo, el flujo sangu\u00edneo de la vena ac\u00edgos y la concentraci\u00f3n de albumina, la concentraci\u00f3n de hemoglobina es un factor con valor predictivo independiente sobre el grado de vasodilataci\u00f3n sist\u00e9mica en estos pacientes. adem\u00e1s, los reultados obtenidos en un estudio prospectivo mostraron que un aumento en la masa eritrocitaria en pacientes con cirrosis y anemia aguda atenua su circulaci\u00f3n hiperdin\u00e1mica de forma, en parte, independiente de la variaciones en la viscosidad sanguinea.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la concentracion sanguinea de hemoglobina sobre las alteraciones hemodinamicas asociadas a la hipertension portal. relacion con el oxido nitrico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la concentracion sanguinea de hemoglobina sobre las alteraciones hemodinamicas asociadas a la hipertension portal. relacion con el oxido nitrico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josep Ignasi Elizalde Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Ter\u00e9s Quiles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Arroyo perez <\/li>\n<li>lLuis Grande posa (vocal)<\/li>\n<li>ricardo Sol\u00ed\u00a0 lamoglia (vocal)<\/li>\n<li>joaquim Balanz\u00f3 tintor\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josep Ignasi Elizalde Fernandez Puesto que la hemoglobina, in vitro, es capaz de modular la actividad biol\u00f3gica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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