{"id":88278,"date":"2018-03-10T00:13:12","date_gmt":"2018-03-10T00:13:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-moleculares-sobre-el-mecanismo-de-accion-de-los-farmacos-antidepresivos\/"},"modified":"2018-03-10T00:13:12","modified_gmt":"2018-03-10T00:13:12","slug":"estudios-moleculares-sobre-el-mecanismo-de-accion-de-los-farmacos-antidepresivos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudios-moleculares-sobre-el-mecanismo-de-accion-de-los-farmacos-antidepresivos\/","title":{"rendered":"Estudios moleculares sobre el mecanismo de acci\u00f3n de los f\u00e1rmacos antidepresivos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Teresa Otano San Mart\u00edn <\/strong><\/h2>\n<p>En el presente trabajo se ha tratado, de una parte, de caracterizar la implicaci\u00f3n de dos receptores serton\u00e9rgicos, 5-ht6 y 5-ht7, cuyo papel funcional en el sistema nervioso central no est\u00e1 aun establecido, en la depresi\u00f3n. Se ha pretendido por otro lado, contribuir al conocimiento y caracterizaci\u00f3n de los eventos moleculares que pudieran tener lugar tras administraci\u00f3n repetida de f\u00e1rmacos antidepresivos que estuvieran relacionados con su eficacia cl\u00ednica, en la esperanza de llegar a entender aspectos de la fisiopatolog\u00eda molecular de los procesos depresivos.  el bloqueo de la s\u00edntesis del receptor 5-ht6 mediante el empleo de un oligonucle\u00f3tido anstisentido no dio lugar a ning\u00fan efecto aparente en el test de la nataci\u00f3n forzada, un modelo animal ampliamente utilizado para valorar la acci\u00f3n de f\u00e1rmacos antidepresivos. Sin embargo, este tratamiento indujo un efecto de tipo ansi\u00f3geno en dos modelos animales, el test de interacci\u00f3n social  y el test del laberinto de la ansiedad. Por otra parte, estudios realizados mediante la administraci\u00f3n de 8-oh dpat en condiciones de inactivaci\u00f3n de receptores por eedq parecen implicar al receptor 5-ht7 en procesos de facilitaci\u00f3n del aprendizaje en roedores.  el estuido de la administraci\u00f3n de f\u00e1rmacos antidpresivos sobre factores de transcripci\u00f3n, mostr\u00f3 que el tratamiento con estos f\u00e1rmacos puede incidir inicialmente sobre la transcripci\u00f3n mediada por gre, a trav\u00e9s de una modulaci\u00f3n positiva directa de la funcionalidad de gr. La adminsitraci\u00f3n prolongada de antidepresivos, implicar\u00eda modificaciones en la expresi\u00f3n g\u00e9nica modulada por factores de transcripci\u00f3n tales como sp1, creb y ap1. Teniendo en cuenta que es necesaria una administraci\u00f3n cr\u00f3nica de los f\u00e1rmacos antidepresivos para poder observar un efecto terap\u00e9utico, es posible que, entre los factores determinantes de su eficacia cl\u00ednica, tengan un papel importante los cambios dirigidos por la uni\u00f3n de estos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios moleculares sobre el mecanismo de acci\u00f3n de los f\u00e1rmacos antidepresivos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios moleculares sobre el mecanismo de acci\u00f3n de los f\u00e1rmacos antidepresivos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Teresa Otano San Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Del Rio Zambrana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Fuentes cubero <\/li>\n<li>joan Salles albria (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez zabalza (vocal)<\/li>\n<li>Jos\u00e9 Masdeu puche (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Teresa Otano San Mart\u00edn En el presente trabajo se ha tratado, de una parte, de caracterizar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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