{"id":88348,"date":"2001-09-01T00:00:00","date_gmt":"2001-09-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-de-farmacos-antiestrogenicos-sobre-la%c2%adneas-celulares-de-cancer-de-mama-humano\/"},"modified":"2001-09-01T00:00:00","modified_gmt":"2001-09-01T00:00:00","slug":"estudio-de-la-actividad-de-farmacos-antiestrogenicos-sobre-la%c2%adneas-celulares-de-cancer-de-mama-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-actividad-de-farmacos-antiestrogenicos-sobre-la%c2%adneas-celulares-de-cancer-de-mama-humano\/","title":{"rendered":"Estudio de la actividad de f\u00e1rmacos antiestrogenicos sobre l\u00edneas celulares de c\u00e1ncer de mama humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Mu\u00f1oz Pozo <\/strong><\/h2>\n<p>En este estudio realiza un an\u00e1lisis comparativo de la actividd de dos sustancias antiestrog\u00e9nicas: un trifenil-etileno cl\u00e1sico, el tamoxifeno, y un antiestr\u00f3genos puro, el ici-182,780 (faslodex). Para ello, como base para el ensayo experimental, se utilizaron dos cultivos celulares de c\u00e1ncer de mama humano; uno con receptores estrog\u00e9nicos positivos (mcf-7) y otro con receptores estrog\u00e9nicos negativos (bt-20).  se estudi\u00f3 el comportamiento de estos dos cultivos ante ambas sustancias mediante curvas de crecimiento y se procedi\u00f3 al an\u00e1lisis de la expresi\u00f3n proteica de las c\u00e9lulas de los cultivos tratados mediante electroforesis de prote\u00ednas generales sobre cuyos geless se practicar\u00e1n diversas tinciones.  tambi\u00e9n realizamos un estudio morfol\u00f3gico bajo microscop\u00eda \u00f3ptica y electr\u00f3nica. Y, por \u00faltimo, se llev\u00f3 a cabo una electroforesis de c\u00e9lulas indiviudales en gel de argarosa (ensayo cometa), lo cual nos permiti\u00f3 determinar el grado de da\u00f1o que provoca cada uno de los tratmientos en el dna de cada una de las c\u00e9lulas.  con el resultado de esta experimentaci\u00f3n y un ordenado an\u00e1lisis estad\u00edstico, pudimos determinar que el antiestr\u00f3geno puro ici-182,780 presentan una mayor capacidad que el tamoxifeno para disminuir la replicaci\u00c2\u00bf oncelular en cultivos celulares de c\u00e1ncer de mama humano, tenga o no receptores estrog\u00e9nicos, y en ausenciad e estimulaci\u00f3n estrog\u00e9nica. Adem\u00e1s, produjo un aumento significativo del \u00e1rea nuclear en c\u00e9lulas con receptores estrog\u00e9nicos positivos. El tratamiento con tamoxifeno no produjo dicha alteraci\u00f3n  la vacuolizaci\u00f3n observada bajo tratamiento de ambos antiestr\u00f3geno en c\u00e9lulas con receptores estrog\u00e9nicos positivos implica una alteraci\u00f3n en la actividad transcripcional del dna ribos\u00f3mico.El ensayo cometa, por su parte, mostr\u00f3 que ambos antiestr\u00f3genos fueron capaces de producir un da\u00f1o significativo en el dna en c\u00e9lulas de ambas estirpes celulares, por lo que probablemen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad de f\u00e1rmacos antiestrogenicos sobre l\u00edneas celulares de c\u00e1ncer de mama humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad de f\u00e1rmacos antiestrogenicos sobre l\u00edneas celulares de c\u00e1ncer de mama humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Mu\u00f1oz Pozo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Le\u00f3n Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Cantillana Martinez <\/li>\n<li>Jos\u00e9 Mar\u00eda Garcia gil (vocal)<\/li>\n<li>Ana Camean fern\u00e1ndez (vocal)<\/li>\n<li>Francisco Abadia molina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Mu\u00f1oz Pozo En este estudio realiza un an\u00e1lisis comparativo de la actividd de dos sustancias antiestrog\u00e9nicas: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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