{"id":88377,"date":"2001-11-01T00:00:00","date_gmt":"2001-11-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-en-fibroblastos-como-factor-patogenico-en-la-esclerosis-sistemica\/"},"modified":"2001-11-01T00:00:00","modified_gmt":"2001-11-01T00:00:00","slug":"estudio-de-la-apoptosis-en-fibroblastos-como-factor-patogenico-en-la-esclerosis-sistemica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-apoptosis-en-fibroblastos-como-factor-patogenico-en-la-esclerosis-sistemica\/","title":{"rendered":"Estudio de la apoptosis en fibroblastos como factor patogenico en la esclerosis sistemica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Santiago Martin <\/strong><\/h2>\n<p>En este estudio se analiza la tasa de proliferaci\u00f3n y apoptosis en secciones cut\u00e1neas de pacientes con es, as\u00ed como la regulaci\u00f3n de la apoptosis que presentan fibroblastos de es y normales en cultivo en respuesta a diferentes est\u00edmulos proapopt\u00f3ticos.  los datos que se presentan demuestran que hay proliferaci\u00f3n de fibroblastos d\u00e9rmicos en secciones de piel de es y de controles inflamatorios a diferencia de lo que se ve en la piel normal. Adem\u00e1s, se observa una ausencia de apoptosis en los fibroblastos de las lesiones esclerod\u00e9rmicas mientras que en otras lesiones inflamatorias s\u00ed se detectan fibroblastos apopt\u00f3ticos. In vitro, los fibroblastos de la es se caracterizan por una suceptibilidad normal a la apoptosis inducida por inhbidores de prote\u00edn-kinasas, la deprivaci\u00f3n de suero o el taxol, y una menor susceptibilidad a la estimulaci\u00f3n de fas. los fibroblastos de es mostraron una regulaci\u00f3n anormal de las prote\u00ednas de la familia bcl-2, consistente en una disminuci\u00f3n de la relaci\u00f3n bax\/bcl-1-bclkl lo que indica una tendencia anti-apopt\u00f3tica. La inhibici\u00f3n de la expresi\u00f3n de bcl-2 con oligunucle\u00f3tidos antisentido normaliz\u00f3 la susceptibilidad a la apoptosis de los fibroblastos de es.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis en fibroblastos como factor patogenico en la esclerosis sistemica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis en fibroblastos como factor patogenico en la esclerosis sistemica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Santiago Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pablos Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Solis  herruzo <\/li>\n<li>Francisco Blanco Garc\u00eda (vocal)<\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<li>Jos\u00e9 Manuel Martin villa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Santiago Martin En este estudio se analiza la tasa de proliferaci\u00f3n y apoptosis en secciones cut\u00e1neas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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