{"id":88395,"date":"2001-12-01T00:00:00","date_gmt":"2001-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analogos-simplificados-de-cardenolidas-sa%c2%adntesis-y-evaluacion-farmacologica\/"},"modified":"2001-12-01T00:00:00","modified_gmt":"2001-12-01T00:00:00","slug":"analogos-simplificados-de-cardenolidas-sa%c2%adntesis-y-evaluacion-farmacologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analogos-simplificados-de-cardenolidas-sa%c2%adntesis-y-evaluacion-farmacologica\/","title":{"rendered":"An\u00e1logos simplificados de cardenolidas, s\u00edntesis y evaluaci\u00f3n farmacol\u00f3gica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Garc\u00eda Sevillano <\/strong><\/h2>\n<p>Se han sintetizado an\u00e1logos de cardenolidas con esqueleto hidroind\u00e9nico que representa a los anillos c y d del sistema esteroide. Los compuestos preparados se agrupan en dos familias, en la primera se incluyen an\u00e1logos insaturados en c-3a y en la segunda an\u00e1logos perhidroind\u00e9nicos con el me-7a y el oh c-3 en disposici\u00f3n beta. Se ha utilizado como material de partida la dicetona de hajos-parrish.  dentro de los insaturados se han introducido diversos restos en la posici\u00f3n c-1 en disposici\u00f3n beta como: hidroximetil, aminometil, ftalimidometil, crotonato de metilo o nitrovinil entre otros. En la posici\u00f3n c-5 se han introducido grupos protectores (dioxolano, ditiano) y otras agrupaciones, fundamentalmente guanidinio.  adem\u00e1s se ha preparado el enati\u00f3mero de la dicetona de hajos-wiechert, la cual mediante transformaciones posteriores condujo al producto final con dos agrupaciones iminoguanidinio en c-1beta y c-5.  en el caso de los an\u00e1logos perhidroind\u00e9nicos se han introducido diversos sustituyentes en la posici\u00f3n c-5; consider\u00e1ndose como requisito imprescindible la configuraci\u00f3n c-5beta para desplazar el equilibrio conformacional hacia la conformaci\u00f3n presente en los digit\u00e1licos naturales. Se han introducido en c-5 agrupaciones como aminas y diversos restos carbonados (nitrometil, malononitrilo, \u00e9steres met\u00edlicos).  a partir de los c-5beta \u00e9steres met\u00edlicos, mediante la v\u00eda de manich se obtienen los metilen derivados, los cuales con el dieno de danishefsky dan lugar a una nueva familia de compuestos con esqueleto b, b-dinor-b-secoesteroide. se han realizado transformaciones sobre dichos an\u00e1logos con el fin de introducir sustituyentes en las posiciones equivalentes a las c-3 y c-17 del esteroide.  evaluaci\u00f3n farmacol\u00f3gica  se han realizado dos tipos de ensayos: de actividad inotr\u00f3pica y de inhibici\u00f3n de las isoenzimas de la atpasa-na+, k+humanas.  los ensayos de actividad inotr\u00f3pica se han realizado solament<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1logos simplificados de cardenolidas, s\u00edntesis y evaluaci\u00f3n farmacol\u00f3gica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1logos simplificados de cardenolidas, s\u00edntesis y evaluaci\u00f3n farmacol\u00f3gica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Garc\u00eda Sevillano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Medarde Agustin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Alcaide <\/li>\n<li>Jos\u00e9 Mar\u00eda Alcaraz (vocal)<\/li>\n<li>josep Bonjoch (vocal)<\/li>\n<li>rosal\u00eda Carr\u00f3n de la calle (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Garc\u00eda Sevillano Se han sintetizado an\u00e1logos de cardenolidas con esqueleto hidroind\u00e9nico que representa a los anillos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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