{"id":88429,"date":"2018-03-10T00:13:25","date_gmt":"2018-03-10T00:13:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-producido-por-la-125-dihidroxivitamina-d3-hidrocortisona-y-deflazacort-sobre-los-niveles-y-expresion-genica-de-los-receptores-de-la-vitamina-d3-en-celulas-umr-106\/"},"modified":"2018-03-10T00:13:25","modified_gmt":"2018-03-10T00:13:25","slug":"efecto-producido-por-la-125-dihidroxivitamina-d3-hidrocortisona-y-deflazacort-sobre-los-niveles-y-expresion-genica-de-los-receptores-de-la-vitamina-d3-en-celulas-umr-106","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-producido-por-la-125-dihidroxivitamina-d3-hidrocortisona-y-deflazacort-sobre-los-niveles-y-expresion-genica-de-los-receptores-de-la-vitamina-d3-en-celulas-umr-106\/","title":{"rendered":"Efecto producido por la 1,25-dihidroxivitamina d3, hidrocortisona y deflazacort sobre los niveles y expresion genica de los receptores de la vitamina d3 en celulas umr-106"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Guerrero Lopez <\/strong><\/h2>\n<p>La respuesta celular a la vitamina d3 depende de los niveles circulantes de este metabolito y de la concentraci\u00f3n de su receptor, ya que cualquier alteraci\u00f3n en los niveles de estos receptores modificar\u00eda la sensibilidad de las c\u00e9lulas para responder a la hormona, alterando finalmente la expresi\u00f3n de todos los genes controlados por la misma. En el hueso y a trav\u00e9s de sus receptores situados en los osteoblastos, esta hormona regula la actividad osteoblastica y osteoclastica.  resulta de gran inter\u00e9s estudiar la regulaci\u00f3n de los niveles de vdr en los osteoblastos, no s\u00f3lo por us propia hormona, sino tambien por otros compuestos que se sabe que regulan de modo heter\u00f3logo, como son los glucocorticoides, y que estan directamente implicados en el desarrollo de diversas patolog\u00edas oseas como la osteoporosis secundaria.  en esta tesis hemos tratado de profundizar sobre aspectos no conocidos en su totalidad de la regulaci\u00f3n del receptor de la vitamina d3. Por otra parte, se ha estudiado la regulaci\u00f3n heter\u00f3loga del receptor producida por dos glucorticoides: uno natural, la hidrocortisona o cortisol y uno sint\u00e9tico, el deflazacort, cuyas modificaciones estructurales le han hecho mas soluble y con menores efectos secundarios sobre el metabolismo \u00f3seo.  es de gran inter\u00e9s conocer no col\u00f3 como estos glucocorticoides afectan los niveles de los receptores de la vitamina d3 sino tambien si el deflazacort produce un efecto diferente que la hidrocortisona sobre estos receptores, pudiendo asi aportar mas luz sobre los mecanismos implicados que hacen al deflazacort un glucocorticoide menos perjudicial que la hidrocortisona sobre el metabolismo \u00f3seo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto producido por la 1,25-dihidroxivitamina d3, hidrocortisona y deflazacort sobre los niveles y expresion genica de los receptores de la vitamina d3 en celulas umr-106<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto producido por la 1,25-dihidroxivitamina d3, hidrocortisona y deflazacort sobre los niveles y expresion genica de los receptores de la vitamina d3 en celulas umr-106 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Guerrero Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Traba Villameytide M. Luisa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cecilio Gimenez martin <\/li>\n<li>Carlos Lozano tonkin (vocal)<\/li>\n<li>federico Hawkins carranza (vocal)<\/li>\n<li>Manuel D\u00edaz curiel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Guerrero Lopez La respuesta celular a la vitamina d3 depende de los niveles circulantes de este [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,9399],"tags":[120314,6730,3917,25753,184528,74034],"class_list":["post-88429","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-cultivo-celular","tag-carlos-lozano-tonkin","tag-cecilio-gimenez-martin","tag-federico-hawkins-carranza","tag-manuel-diaz-curiel","tag-rosa-guerrero-lopez","tag-traba-villameytide-m-luisa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88429"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88429\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}