{"id":88490,"date":"2018-03-10T00:13:29","date_gmt":"2018-03-10T00:13:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-qua%c2%admica-y-propiedades-biologicas-del-acido-allo-colico-3alfa-7alfa-12alfa-trihihidroxi-5alfa-colanoico\/"},"modified":"2018-03-10T00:13:29","modified_gmt":"2018-03-10T00:13:29","slug":"sintesis-qua%c2%admica-y-propiedades-biologicas-del-acido-allo-colico-3alfa-7alfa-12alfa-trihihidroxi-5alfa-colanoico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sintesis-qua%c2%admica-y-propiedades-biologicas-del-acido-allo-colico-3alfa-7alfa-12alfa-trihihidroxi-5alfa-colanoico\/","title":{"rendered":"Sintesis qu\u00edmica y propiedades biologicas del acido allo-colico (3alfa-7alfa-12alfa-trihihidroxi-5alfa-colanoico)"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mendoza G\u00f3mez M. Encarnaci\u00f3n <\/strong><\/h2>\n<p>En sistemas fisiol\u00f3gicos y patol\u00f3gicos pueden aparecer alteraciones en la s\u00edntesis de \u00e1cidos biliares, dando lugar a mol\u00e9culas inusuales como los allo-\u00e1cidos biliares. Estos aparecen en humanos durante la vida fetal y en adultos con determinadas patolog\u00edas hep\u00e1ticas (cirrosis, met\u00e1stasis y hepatocarcinoma).  el primer objetivo de esta tesis doctoral fue obtener una herramienta que permitiese estudiar el comportamiento biol\u00f3gico de los allo-\u00e1cidos biliares, para ello se sintetiz\u00f3 el \u00e1cido allo-c\u00f3lico. A continuaci\u00f3n se llevaron a cabo estudios de transporte hepatobiliar en ratones \u00abin vivo\u00bb, e \u00abin vitro\u00bb en modelos de expresi\u00f3n de prote\u00ednas transprotadoras de \u00e1cidos biliares utilizando una l\u00ednea celular de ovario de hamster chino cho y oocitos de xenopus laevis.  tambi\u00e9n se estudi\u00f3 si la hepatocarcinog\u00e9nesis experimental ten\u00eda repercusiones en la cantidad y proporci\u00f3n de las diferentes especies moleculares de \u00e1cidos biliares presentes en el n\u00facleo de las c\u00e9lulas hep\u00e1ticas y la vectorializaci\u00f3n hacia el n\u00facleo de este \u00e1cido biliar plano compar\u00e1ndolo con el \u00e1cido c\u00f3lico. por \u00faltimo se estudi\u00f3 si el \u00e1cido allo-c\u00f3lico afecta a procesos de apoptosis, diferenciaci\u00f3n y proliferaci\u00f3n de las c\u00e9lulas del par\u00e9nquima hep\u00e1tico.  el \u00e1cido allo-c\u00f3lico presenta un comportamiento colef\u00edlico similar al de otros \u00e1cidos biliares. Se diferencia de ellos por su marcada capacidad para traslocarse al n\u00facleo de las c\u00e9lulas hep\u00e1ticas e inducir apoptosis, lo que sugiere que puede jugar un papel en el concierto de se\u00f1ales que participan en los procesos de remodelaci\u00f3n tisular durante la organog\u00e9nesis y la regeneraci\u00f3n hep\u00e1tica. Los resultados de esta tesis doctoral abre una interesante v\u00eda de investigaci\u00f3n que deber\u00e1 abordar el estudio de esta hip\u00f3tesis, as\u00ed como el posible papel del \u00e1cido allo-c\u00f3lico en situaciones patol\u00f3gicas como la hepatocarcinog\u00e9nesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis qu\u00edmica y propiedades biologicas del acido allo-colico (3alfa-7alfa-12alfa-trihihidroxi-5alfa-colanoico)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis qu\u00edmica y propiedades biologicas del acido allo-colico (3alfa-7alfa-12alfa-trihihidroxi-5alfa-colanoico) <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mendoza G\u00f3mez M. Encarnaci\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  angeles Serrano garcia <\/li>\n<li>rosal\u00eda Carr\u00f3n de la calle (vocal)<\/li>\n<li>diego G\u00f3mez-coronado (vocal)<\/li>\n<li> Bravo del moral Ana M\u00aa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mendoza G\u00f3mez M. Encarnaci\u00f3n En sistemas fisiol\u00f3gicos y patol\u00f3gicos pueden aparecer alteraciones en la s\u00edntesis de \u00e1cidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,156,1323,9386],"tags":[184619,184095,1109,39355,184618,39332],"class_list":["post-88490","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-patologia","category-patologia-experimental","category-salamanca","tag-bravo-del-moral-ana-ma","tag-diego-gomez-coronado","tag-jose-juan-garcia-marin","tag-maria-angeles-serrano-garcia","tag-mendoza-gomez-m-encarnacion","tag-rosalia-carron-de-la-calle"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88490"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88490\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}