{"id":88509,"date":"2018-03-10T00:13:29","date_gmt":"2018-03-10T00:13:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-funcionales-de-la-fosforilacion-de-la-proteina-p-del-virus-respiratorio-sincitial-humano-vrsh\/"},"modified":"2018-03-10T00:13:29","modified_gmt":"2018-03-10T00:13:29","slug":"estudios-funcionales-de-la-fosforilacion-de-la-proteina-p-del-virus-respiratorio-sincitial-humano-vrsh","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-funcionales-de-la-fosforilacion-de-la-proteina-p-del-virus-respiratorio-sincitial-humano-vrsh\/","title":{"rendered":"Estudios funcionales de la fosforilacion de la proteina p del virus respiratorio sincitial humano (vrsh)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Mar\u00eda Asenjo Vila <\/strong><\/h2>\n<p>El virus respiratorio sincitial humano (vrsh) es el principal agente causal de infecciones respiratorias agudas que requieren hospitalizacion en ni\u00f1os menores de dos a\u00f1os. Tambien causa infecciones respiratorias agudas en ancianos. Hasta el momento es un pat\u00f3geno no controlado sanitariamente. las vacunas, compuestos antivirales y humanizaci\u00f3n de anticuerpos neutralizantes especificos son las tres herramientas que, de acuerdo con las caracteristicas de la infeccion y de las poblaciones mayoritariamente afectadas, pueden controlar las infecciones. Este estudio pretende determinar la funcionalidad de la fosforilacion de la proteina p, una fosfoproteina estructural de las nucleocapsidas virales. Resultados anteriores de nuestro laboratorio demostraron que la proteina p se fosforila en residuos de serina localizados en dos regiones separadas de la moelcula: region i o central y region ii o carboxilo terminal. Este trabajo ha servido para definir una fosforilaci\u00f3n nueva estrictamente regulada en la regi\u00f3n amino terminal de la mol\u00e9cula, a la que hemos denominado region iii, y determinar que la fosforilacion de la region i que al igual que la de la region ii pensabamos que era constitutiva, tambien esta parcialmente regulada. Hemos identificado las prote\u00ednas quinasas y fosfatasas que controlan dichas regiones asi como la casi totalidad de los residuos que se modifican en la region iii.  se ha comprobado que la fosforilacion de las regiones i y ii en dispensable para la funcionalidad de la proteina en transcripicon y replicacion aunque incrementa la actividad de la proteina p rn en dichos procesos.  se ha demostrado que la prote\u00edna p es capaz de oligomerizar formando tetrameros y se ha definido un dominio probable de oligomerizaci\u00f3n, para este proceso es dispensable la fosforilaci\u00f3n de las regiones i y ii, y quizas, es esencial la fosforilaci\u00f3n de la region iii, en el residuo t46.  todos los resultados han sido empleados en la constru<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios funcionales de la fosforilacion de la proteina p del virus respiratorio sincitial humano (vrsh).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios funcionales de la fosforilacion de la proteina p del virus respiratorio sincitial humano (vrsh). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Mar\u00eda Asenjo Vila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Nieves Villanueva Vico<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Hermoso  nu\u00f1ez <\/li>\n<li>Juan Ortin monton (vocal)<\/li>\n<li>Luis EnJuan es sanchez (vocal)<\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Mar\u00eda Asenjo Vila El virus respiratorio sincitial humano (vrsh) es el principal agente causal de infecciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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