{"id":88543,"date":"2018-03-10T00:13:33","date_gmt":"2018-03-10T00:13:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-de-la-expresion-de-genes-reguladores-del-ciclo-celular-y-de-la-apoptosis-p53-p21-p16-bax-y-bcl-2-inducida-por-quimioterapia-en-el-urotelioma-vesical-localmente-avanzado\/"},"modified":"2018-03-10T00:13:33","modified_gmt":"2018-03-10T00:13:33","slug":"modificacion-de-la-expresion-de-genes-reguladores-del-ciclo-celular-y-de-la-apoptosis-p53-p21-p16-bax-y-bcl-2-inducida-por-quimioterapia-en-el-urotelioma-vesical-localmente-avanzado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificacion-de-la-expresion-de-genes-reguladores-del-ciclo-celular-y-de-la-apoptosis-p53-p21-p16-bax-y-bcl-2-inducida-por-quimioterapia-en-el-urotelioma-vesical-localmente-avanzado\/","title":{"rendered":"Modificaci\u00f3n de la expresi\u00f3n de genes reguladores del ciclo celular y de la apoptosis (p53, p21, p16, bax y bcl-2) inducida por quimioterapia en el urotelioma vesical localmente avanzado."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Alonso Romero <\/strong><\/h2>\n<p>Uno de los campos m\u00e1s interesantes dentro de la biolog\u00eda celular es de los genes relacionados con el ciclo celular y la apoptosis. En varios estudios, el estado de estos genes ha mostrado valor pron\u00f3stico e implicaciones terap\u00e9uticas en pacientes diagnosticados de c\u00e1ncer.  en este trabajo estudiamos mediante inmunihistoqu\u00edmica la modificaci\u00f3n de algunos genes relacionados con el control del ciclo celular y con el control de la apoptosis(p53,p21,p16,bax y bcl-2)en pacientes diagnosticados de urotelioma vesical localmente avanzado tras la administraci\u00f3n de quimioterapia. tambi\u00e9n estudiamos la relaci\u00f3n de estos genes con el valor pron\u00f3stico, en cuanto a supervivencia y supervivencia libre de enfermedad, y con las sensibilidad al tratamiento aplicado.  tras la administraci\u00f3n de quimioterapia, hay reducci\u00f3n de forma significativa de la expresi\u00f3n de p53 (p=0,03), p16(p=0,04) y bcl-2(p=0,01). No existe diferencia significativa de la expresi\u00f3n de bax y p21, aunque existe tendencia a la disminuci\u00f3n de la expresion de p21(p=0,06) y al aumento de bax(p=0,06).  las variables relacionados con la supervivencia global de estos pacientes han sido: la expresi\u00f3n de bcl-2 antes de la quimioterapia y la modificaci\u00f3n del grado de tinci\u00f3n de p16y p21.  las variables relacionadas con la supervivencia libre de enfermedad en estos pacientes han sido: la expresi\u00f3n de bc1-2 antes de la quimioterapa, la modificaci\u00f3n de la expresi\u00f3n de p53 y bax y la respuesta cl\u00ednico-patol\u00f3gica conseguida con el tratamiento.  tras la quimioterapia, la c\u00e9lula tumoral urotelial tiene reducido su potencial para progresar a lo largo del ciclo celular y aumentada su capacidad para la entrada en la apoptosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaci\u00f3n de la expresi\u00f3n de genes reguladores del ciclo celular y de la apoptosis (p53, p21, p16, bax y bcl-2) inducida por quimioterapia en el urotelioma vesical localmente avanzado.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaci\u00f3n de la expresi\u00f3n de genes reguladores del ciclo celular y de la apoptosis (p53, p21, p16, bax y bcl-2) inducida por quimioterapia en el urotelioma vesical localmente avanzado. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Alonso Romero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>rubio Garc\u00eda D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>enrique Aranda aguilar (vocal)<\/li>\n<li>alfredo Carrato mona (vocal)<\/li>\n<li>Andr\u00e9s Cervantes ruperez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Alonso Romero Uno de los campos m\u00e1s interesantes dentro de la biolog\u00eda celular es de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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