{"id":88577,"date":"2018-03-10T00:13:33","date_gmt":"2018-03-10T00:13:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hormona-de-crecimiento-en-un-modelo-experimental-de-hipercatabolismo-proteico\/"},"modified":"2018-03-10T00:13:33","modified_gmt":"2018-03-10T00:13:33","slug":"efecto-de-la-hormona-de-crecimiento-en-un-modelo-experimental-de-hipercatabolismo-proteico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-hormona-de-crecimiento-en-un-modelo-experimental-de-hipercatabolismo-proteico\/","title":{"rendered":"Efecto de la hormona de crecimiento en un modelo experimental de hipercatabolismo proteico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Cant\u00f3n Blanco <\/strong><\/h2>\n<p>Introduccion  la hormona de crecimiento gh act\u00faa sobre la composici\u00f3n corporal y presenta diferentes acciones sobre el metabolismo hidrocarbonado, lip\u00eddico y proteico. estudios in vivo e in vitro han demostrado el efecto anab\u00f3lico de la gh por su acci\u00f3n estimuladora sobre la s\u00edntesis de prote\u00ednas. Sus propiedades la convierten en un tratamiento de potencial utilidad en situaciones de hipercatabolismo proteico, como las que experimentan los enfermos en las unidades de cuidados intensivos.  hip\u00f3tesis y objetivos  la hip\u00f3tesis de trabajo es que la administraci\u00f3n de gh, debido a su acci\u00f3n anab\u00f3lica, podr\u00eda tener un efecto beneficioso en estas situaciones:  objetivos  1,- evaluar si el tratamiento con gh es beneficioso en un modelo experimental de hipercatabolismo inducido por dosis elevadas de glucocorticoides.  2,- examinar el efecto de la gh sobre los niveles de acth, corticosterona e igf-1.  3,- estudiar el efecto de la gh sobre la expresi\u00f3n del receptor gulocorticoide rg, evaluando mediante pcr.  4,- determinar mediante northern blot el efecto de la gh sobre la expresi\u00f3n de la tiros\u00edn aminotransferasa tat, marcador de acci\u00f3n glucocorticoide.  material y metodos  50 ratas wistar macho se distribuyeron de forma aleatoria en 5 grupos de tratamiento. Grupo a: gh subcut\u00e1nea (s.C.) Y placebo oral; gurpo b: placebo s.C. Y dexametasona (dex) oral; grupo c: gh s.C. Y dex. Oral; grupo d: placebo s.C. Y placebo oral; grupo e: no tratamiento. Dosis de gh: 1,6 mg\/kg\/d\u00eda durante 7 d\u00edas. Dosis de dex.: 3 mg\/kg\/d\u00eda durante 7 d\u00edas. Placebo: suero salino est\u00e9ril. El peso de los animales se determin\u00f3 a diario y su sacrificio se realiz\u00f3 24 horas despu\u00e9s de la \u00faltima dosis. Determinaciones hormonales: coritocosterona, igf-1 (ria) y acth (irma). Expresi\u00f3n del rg hep\u00e1tico (pcr). Expresi\u00f3n de la tat hep\u00e1tica (nortern blot). An\u00e1lisis estad\u00edstico: descriptivo y comparativo (anova\/t-student, si exist\u00eda homogeneidad de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la hormona de crecimiento en un modelo experimental de hipercatabolismo proteico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la hormona de crecimiento en un modelo experimental de hipercatabolismo proteico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Cant\u00f3n Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Sim\u00f3 Canonge<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>susan Webb youndale (vocal)<\/li>\n<li>Manuel Armengol carrasco (vocal)<\/li>\n<li>cristina Hern\u00e1ndez pascual (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Cant\u00f3n Blanco Introduccion la hormona de crecimiento gh act\u00faa sobre la composici\u00f3n corporal y presenta diferentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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