{"id":88683,"date":"2001-01-02T00:00:00","date_gmt":"2001-01-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/promorcion-de-la-penetracion-transdermica-de-metotrexato\/"},"modified":"2001-01-02T00:00:00","modified_gmt":"2001-01-02T00:00:00","slug":"promorcion-de-la-penetracion-transdermica-de-metotrexato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/promorcion-de-la-penetracion-transdermica-de-metotrexato\/","title":{"rendered":"Promorci\u00f3n de la penetraci\u00f3n transd\u00e9rmica de metotrexato"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alvarez Figueroa M. Javiera <\/strong><\/h2>\n<p>El metotrexato(mtx) ha demostrado ser un f\u00e1rmaco efectivo para el tratamiento de la psoriasis cuando se emplea por v\u00eda oral o parenteral y por per\u00edodos de tiempo prolongados. Sin embargo, como se han observado numerosos efectos asociados a su uso sist\u00e9mico se ha intentado su administraci\u00f3n por v\u00eda local. Debido a las caracter\u00edsticas qu\u00edmicas que este principio activo posee (peso moleculr, solubilidad, lipofilia, etc) penetra escasamente a trav\u00e9s de la piel por mecanismos de difusi\u00f3n pasiva. Es por esto, que en este trabajo se estudiaron diferentes t\u00e9cnicas de iontoforesis, que consiste en la aplicaci\u00f3n de corriente el\u00e9ctrica a trav\u00e9s de la piel, mostr\u00f3 ser una t\u00e9cnica ventajosa respecto a la difusi\u00f3n pasiva. Adem\u00e1s, cuando se combin\u00f3 esta t\u00e9cnica con el uso de hidrogeles como veh\u00edculos de administraci\u00f3n transd\u00e9rmica, tambi\u00e9n se observ\u00f3 un aumento en la penetraci\u00f3n del mtx. posteriolmente, se estudi\u00f3 el empleo de microemulsiones como veh\u00edculos de administraci\u00f3n t\u00f3pica, ya que se ha estudiado que estos sistemas act\u00faan como promotores de la absorci\u00f3n percut\u00e1nea. En este \u00faltimo caso, al igual que en los casos anteriores, tambi\u00e9n se observ\u00f3 un aumento en la penetraci\u00f3n transd\u00e9rmica de mtx obtenida en este estudio, hace posible su adminsitraci\u00f3n por via topica. Sin embargo, por no conocerse las concentraciones locales necesarias para su uso en el tratamiento local de psoriasis, no podemos afirmar que el incremento en las concentraciones t\u00f3picas alcanzadas son las adecuadas para alcanzar el efecto terap\u00e9utico requerido. No obstante, tanto las t\u00e9cnicas como los veh\u00edculos de administraci\u00f3n transd\u00e9rmica empleados en este estudio, son vers\u00e1tiles y pueden ser modificados y dise\u00f1ados para lograr un aumento a\u00fan mayor de la penetraci\u00f3n cut\u00e1nea de este principio activo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Promorci\u00f3n de la penetraci\u00f3n transd\u00e9rmica de metotrexato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Promorci\u00f3n de la penetraci\u00f3n transd\u00e9rmica de metotrexato <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alvarez Figueroa M. Javiera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Blanco M\u00e9ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Mart\u00ednez pacheco <\/li>\n<li>Mar\u00eda  rosa Jimenez castellanos ballesteros (vocal)<\/li>\n<li>Jos\u00e9 Luis Lastres garcia (vocal)<\/li>\n<li>Mar\u00eda de la paloma Ballesteros papantonakis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvarez Figueroa M. Javiera El metotrexato(mtx) ha demostrado ser un f\u00e1rmaco efectivo para el tratamiento de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189,977],"tags":[184925,21090,5847,6886,3013,3307],"class_list":["post-88683","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-santiago-de-compostela","tag-alvarez-figueroa-m-javiera","tag-jose-blanco-mendez","tag-jose-luis-lastres-garcia","tag-maria-de-la-paloma-ballesteros-papantonakis","tag-maria-rosa-jimenez-castellanos-ballesteros","tag-ramon-Martinez-pacheco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88683"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88683\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}