{"id":88693,"date":"2001-01-02T00:00:00","date_gmt":"2001-01-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-farmacologica-de-nuevos-antagonistas-cck-1-de-la-colecistoquinina\/"},"modified":"2001-01-02T00:00:00","modified_gmt":"2001-01-02T00:00:00","slug":"caracterizacion-farmacologica-de-nuevos-antagonistas-cck-1-de-la-colecistoquinina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-farmacologica-de-nuevos-antagonistas-cck-1-de-la-colecistoquinina\/","title":{"rendered":"Caracterizaci\u00f3n farmacol\u00f3gica de nuevos antagonistas cck-1 de la colecistoquinina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Latorre Izquierdo <\/strong><\/h2>\n<p>En el presente trabajo se desarroll\u00f3 el estudio farmacol\u00f3gico de un elevado n\u00famero de nuevos compuestos sintetizados en el instituto de qu\u00edmica m\u00e9dica del csic de Madrid, con el fin de determinar su posible actividad antagonista sobre los receptores de cck. Entre los compuestos ensayados, destacaron por su alta afinidad y selectividad cck1 los derivados pirimid\u00ednicos. en ensayos en \u00f3rgano aislado y en suspensi\u00f3n de acinos pancre\u00e1ticos se confirm\u00f3 su elevada actividad antagonsita cck1.  en funci\u00f3n de los resultados en estudios in vitro, se seleccionaron los derivados piridopirimid\u00ednicos e-333 y sus an\u00e1logos e-422 y e-423, m\u00e1s estables a la degradaci\u00f3n qu\u00edmica y el medio \u00e1cido, para no caracterizaci\u00f3n farmacol\u00f3gica m\u00e1s amplia. As\u00ed, en estudios de pancretitis aguda inducida por cerule\u00edna, los tres derivados presentaron efecto protector, destacando el compuesto e-423 con una mayor acitividad y biodisponibilidad oral.  en la pancreatitis aguda inducida por ligadura del conducto com\u00fan pancre\u00e1tico-biliar en ratas, este compuesto tambi\u00e9n present\u00f3 una actividad protectora, similar al devazepide. En los ensayos de actividad motora espont\u00e1nea los tres derivados revirtieron totalmente la hipolocomoci\u00f3n inducida por cck8s.  los compuestos e-422 y e-423 presentaron una acci\u00f3n m\u00e1s larga que su an\u00e1logo e-333, lo que sugiere una mayor biodisponibilidad oral. La administraci\u00f3n de los compuestos junto con morfina potenci\u00f3 la analgesia opioide. Adem\u00e1s los compuestos e422 y e-423 disminuyeron la tolerancia inducida por morfina, confirm\u00e1dose la implicaci\u00f3n de los dos su tipos de receptores de cck en la interacci\u00f3n con el sistema opioide. En los estudios de actividad ansiol\u00edtica los tres compuestos se mostraron activos en el test  de la caja de dos compartimentos.  el test del laberinto elevado confirm\u00f3 el car\u00e1cter ansiol\u00edtico de los compuestos e-333 y e-423, mientras que e-422 fue inactivo. Estos resultados sugieren<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n farmacol\u00f3gica de nuevos antagonistas cck-1 de la colecistoquinina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n farmacol\u00f3gica de nuevos antagonistas cck-1 de la colecistoquinina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Latorre Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Edurne Cenarruzabeitia Sagarminaga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  pilar Fernandez otero <\/li>\n<li> Grac\u00eda l\u00f3pez Mar\u00eda  teresa (vocal)<\/li>\n<li>Luis m Botana l\u00f3pez (vocal)<\/li>\n<li>berta esperanza Lasheras aldaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Latorre Izquierdo En el presente trabajo se desarroll\u00f3 el estudio farmacol\u00f3gico de un elevado n\u00famero de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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