{"id":88712,"date":"2001-02-02T00:00:00","date_gmt":"2001-02-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-analgesicos-relacionados-con-la-homeostasis-de-calcio-a-nivel-espinal-en-ratas\/"},"modified":"2001-02-02T00:00:00","modified_gmt":"2001-02-02T00:00:00","slug":"mecanismos-analgesicos-relacionados-con-la-homeostasis-de-calcio-a-nivel-espinal-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-analgesicos-relacionados-con-la-homeostasis-de-calcio-a-nivel-espinal-en-ratas\/","title":{"rendered":"\u00abmecanismos analg\u00e9sicos relacionados con la homeostasis de calcio a nivel espinal en ratas\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alvarez Vega Marco Antonio <\/strong><\/h2>\n<p>En el presente trabajo se han estudiado los efectos sobre la sensibilidad dolorosa de farmacos capaces de modificar la homeostasis del calcio anivel de la m\u00e9dula espinal de la rata. Partiendo del resultado inicial de que la administraci\u00f3n intratecal de inhibidores de calmodulina produce analgesia medible en diferentes tests, se ha realizado un estudio comparativo de los efectos del inhibidor de calmodulina calmidazoliun, la morfina y la bupivaca\u00edna sobre el comportamiento nociceptivo de mordido,lamido y rascado(bsl) producido por inyecci\u00f3n espinal de nmda y el agonista del receptor nk1 septide. Los resultados obtenidos muestran como el calmidazolium presenta en estas pruebas una potencia y eficacia no inferior a la del opi\u00e1ceo y el anest\u00e9sico local. Se han demostrado asimismo los efectos analg\u00e9sicos espinales del dantroleno (inhibidor del receptor de la rianodina) y de la thapsigargina(inhibidor de la calcio atpasa reticular) que resultan eficaces en test f\u00e1sicos (tail-flick) pero no t\u00f3nicos(formalina), y su capacidad para inhibir selectivamente el bsl producido por septide pero no por nmda o ampa. Asimismo, se ha tratado de caracterizar el efecto analg\u00e9sico que parad\u00f3jicamente induce en el test de tail-flick la administraci\u00f3n intratecal de nmda una vez superada la fase excitadora inicial. Por \u00faltimo,mediante t\u00e9cnicas inmunohistoqu\u00edmicas seha evidenciado como la administraci\u00f3n intratecal de nmda y septide afecta a la detecci\u00f3n espinal de las prote\u00ednas ligantes del calcio calmodulina, neurocalcina y s100.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abmecanismos analg\u00e9sicos relacionados con la homeostasis de calcio a nivel espinal en ratas\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abmecanismos analg\u00e9sicos relacionados con la homeostasis de calcio a nivel espinal en ratas\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alvarez Vega Marco Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Menendez Antolin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Andres rodriguez-trelles Fernando de <\/li>\n<li>angela Alsasua del valle (vocal)<\/li>\n<li>agustin Hidalgo balsera (vocal)<\/li>\n<li>Mar\u00eda no Ruiz gayo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvarez Vega Marco Antonio En el presente trabajo se han estudiado los efectos sobre la sensibilidad dolorosa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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