{"id":88739,"date":"2001-02-02T00:00:00","date_gmt":"2001-02-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-los-efectos-de-la-toxina-acido-domoico-sobre-la-neurotransmision-dopaminergia-in-vivo-mediante-dialisis-cerebral\/"},"modified":"2001-02-02T00:00:00","modified_gmt":"2001-02-02T00:00:00","slug":"caracterizacion-de-los-efectos-de-la-toxina-acido-domoico-sobre-la-neurotransmision-dopaminergia-in-vivo-mediante-dialisis-cerebral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-de-los-efectos-de-la-toxina-acido-domoico-sobre-la-neurotransmision-dopaminergia-in-vivo-mediante-dialisis-cerebral\/","title":{"rendered":"Caracterizaci\u00f3n de los efectos de la toxina \u00e1cido domoico sobre la neurotransmisi\u00f3n dopamin\u00e9rgia \u00abin vivo\u00bb mediante di\u00e1lisis cerebral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Arias Quintela <\/strong><\/h2>\n<p>En 1990, el \u00e1cido domoico fue identificado en mejillones cultivados e nla isla prince edward (canad\u00e1), como el contaminante t\u00f3xico responsable de un grave envenenamiento. Biscoe (1975) clasific\u00f3 a esta toxina como un amino\u00e1cido tricarbox\u00edlico, an\u00e1logo estructural al \u00e1cido glut\u00e1mico.El s\u00edndrome ocasionado por el \u00e1cido domoico se denomin\u00f3 intoxicaci\u00f3n amn\u00e9sica, caracterizado por s\u00edntomas gastrointestinales y neurol\u00f3gicos. Los signos neurol\u00f3gicos provodados por esta toxina son comparables a los que se producen en un estado epil\u00e9ptico, por lo que resulta especialmente interdante estudiar la posible interrelaci\u00f3n entre esta neurotoxina y la neurotransmisi\u00f3n deopamin\u00e9rgica. no obstante, hay pocos estudios que aborden, desde un punto de vista in vivo, la relaci\u00f3n entre el \u00e1cido domoico y la liberaci\u00f3n de la dopamina y sus metablotios, en el n\u00facleo estriado de rata consciente y en libre movimiento. Por ello, el objetivo de esta tesis doctoral se centr\u00f3 en caracterizar el mecanismo de acci\u00f3n de la neurotroxina, \u00e1cido domoico, sobre los niveles estriatales de la dopamina en rata. La t\u00e9cnica de microdi\u00e1lisis cerebral fue utilziada para la administraci\u00f3n y recogida de muestras del l\u00edquido extracelular del n\u00facleo estriado. Para la cuantificaci\u00f3n de la dopamina y sus metabolitos \u00e1cidos en las muestras de dailizado, se optimizar\u00f3n las caracter\u00edsticas anal\u00edticas de la cromatograf\u00eda l\u00edquida de alta eficacia (hplc) unida a detecci\u00f3n electroqu\u00edmica. Adem\u00e1s, se caracteriz\u00f3 que tipo de receptor glutamat\u00e9rgico interact\u00faa con el \u00e1cido domoico en las neuronas dopamin\u00e9rgica mediante la aplicaci\u00f3n de diversos tipos de antagnoistas glutamat\u00e9rgicos. Y por \u00faltimo, se determin\u00f3 el mecanismo de acci\u00f3n de esta toxina sobre la liberaci\u00f3n estriatal de la dopamina mediante la administraci\u00f3n de distintos f\u00e1rmacos dopamin\u00e9rgicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de los efectos de la toxina \u00e1cido domoico sobre la neurotransmisi\u00f3n dopamin\u00e9rgia \u00abin vivo\u00bb mediante di\u00e1lisis cerebral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de los efectos de la toxina \u00e1cido domoico sobre la neurotransmisi\u00f3n dopamin\u00e9rgia \u00abin vivo\u00bb mediante di\u00e1lisis cerebral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Arias Quintela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Vigo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Alfonso  Pallares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel alejo Aldegunde villar <\/li>\n<li>Manuel angel Pombal  diego (vocal)<\/li>\n<li>Ana Gago mart\u00ednez (vocal)<\/li>\n<li> Miguez besada M\u00aa isabel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Arias Quintela En 1990, el \u00e1cido domoico fue identificado en mejillones cultivados e nla isla prince [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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