{"id":88760,"date":"2001-06-02T00:00:00","date_gmt":"2001-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anta%c2%adgeno-menor-de-histocompatibilidad-ha-1-implicacion-en-el-transplante-alogenico-de-progenitores-hematopoyeticos-a-partir-de-donante-emparentado-hla-identico\/"},"modified":"2001-06-02T00:00:00","modified_gmt":"2001-06-02T00:00:00","slug":"anta%c2%adgeno-menor-de-histocompatibilidad-ha-1-implicacion-en-el-transplante-alogenico-de-progenitores-hematopoyeticos-a-partir-de-donante-emparentado-hla-identico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/anta%c2%adgeno-menor-de-histocompatibilidad-ha-1-implicacion-en-el-transplante-alogenico-de-progenitores-hematopoyeticos-a-partir-de-donante-emparentado-hla-identico\/","title":{"rendered":"Ant\u00edgeno menor de histocompatibilidad ha-1. implicaci\u00f3n en el transplante alog\u00e9nico de progenitores hematopoy\u00e9ticos a partir de donante emparentado hla-id\u00e9ntico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Ignacio Ar\u00f3stegui Gorospe <\/strong><\/h2>\n<p>El ant\u00edgeno menor de histocompatibilidad ha-1 es un sistema dial\u00e9lico, de tal manera que el fenotipo ha-1 positivo es conferido por el p\u00e9ptido codificado por el alelo ha-1h, mientras el fenotipo negativo lo es por el alelo ha-1r. En los art\u00edculos presentes en la literatura cient\u00edfica las \u00fanicas diferencias entre ambos alelos se encuentran en las posiciones 500 y 504 del cdna.  en el primer objetivo de la presente tesis se analizan las frecuencias al\u00e9licas del ant\u00edgeno menro ha-1 en individuos no emparentados extra\u00eddos de la poblaci\u00f3n catalana. En \u00e9l se pone de manifiesto un fenotipo ha-1 positivo del 55,2% , lo cual contrasta con el 68 y 69% encontrados en poblaciones cauc\u00e1sticas estadounidense y holandesa respectivamente.  el segundo objetivo se centra en la aplicaci\u00f3n de la t\u00e9cnica de an\u00e1lisis conformacional del dna de doble hebra rsca para la asignaci\u00f3n al\u00e9lica del ant\u00edgeno menor ha-1. Los resultados de este estudio ponen de manifiesto la exigencia de la secuencia tttat en la posici\u00f3n intr\u00f3nica 214-218, asociada al alelo ha-1r y ausente en el alelo ha-1h. Igualmente se ha identificado 2 nuevas variantes al\u00e9licas (ha-1rdel5 y ha-1hins5) y polimorfismos en las posiciones intr\u00f3nicas 65 y 130. El an\u00e1lisis comparativo de los resultados obtenidos por los m\u00e9todos pcr-ssp y rsca, en las mismas muestras, ha puesto de manifiesto una correlaci\u00f3n superior al 99% entre ambos m\u00e9todos.  en el tercer objetivo de la tesis se presenta un estudio multic\u00e9ntrico (14 hospitles espa\u00f1oles) y retrospectivo, que engloba 225 emparejamietnos donante-receptor, para analizar el papel de la disparidad en el ant\u00edgeno menor ha-1 entre donantes y receptor con las complicaciones post-trasplante en el transplante alog\u00e9nico de progenitores hematopoy\u00e9cticos a partir de donante emparentado hla-id\u00e9ntico. Este estuido pone de manifiesto el papel de factor de riesgo de dicha disparidad para el desarrollo de grados ii-iv de enfermedad del injer<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ant\u00edgeno menor de histocompatibilidad ha-1. implicaci\u00f3n en el transplante alog\u00e9nico de progenitores hematopoy\u00e9ticos a partir de donante emparentado hla-id\u00e9ntico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ant\u00edgeno menor de histocompatibilidad ha-1. implicaci\u00f3n en el transplante alog\u00e9nico de progenitores hematopoy\u00e9ticos a partir de donante emparentado hla-id\u00e9ntico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Ignacio Ar\u00f3stegui Gorospe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Gra\u00f1ena Batista<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rutllant ba\u00f1eres miquel lLuis <\/li>\n<li>Miguel Lopez botet arbona (vocal)<\/li>\n<li>alejandro Madrigal j. (vocal)<\/li>\n<li>jaume Martorell pons (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Ignacio Ar\u00f3stegui Gorospe El ant\u00edgeno menor de histocompatibilidad ha-1 es un sistema dial\u00e9lico, de tal manera [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,195,450,139,156],"tags":[219,185048,20470,142284,6524,14219],"class_list":["post-88760","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-hemopatologia","category-inmunopatologia","category-medicina-interna","category-patologia","tag-alberto-granena-batista","tag-alejandro-madrigal-j","tag-jaume-martorell-pons","tag-juan-ignacio-arostegui-gorospe","tag-miguel-lopez-botet-arbona","tag-rutllant-baneres-miquel-lluis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88760"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88760\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}