{"id":88779,"date":"2001-08-02T00:00:00","date_gmt":"2001-08-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-imipramina-sobre-la-modulacion-del-sistema-encefalinergico-en-el-sistema-nervioso-central-de-la-rata\/"},"modified":"2001-08-02T00:00:00","modified_gmt":"2001-08-02T00:00:00","slug":"efecto-de-la-imipramina-sobre-la-modulacion-del-sistema-encefalinergico-en-el-sistema-nervioso-central-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-de-la-imipramina-sobre-la-modulacion-del-sistema-encefalinergico-en-el-sistema-nervioso-central-de-la-rata\/","title":{"rendered":"Efecto de la imipramina sobre la modulaci\u00f3n del sistema encefalin\u00e9rgico en el sistema nervioso central de la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adolfo Varona Guti\u00e9rrez <\/strong><\/h2>\n<p>Las patolog\u00edas depresivas son uno de los principales problemas sanitarios en los pa\u00edses desarrollados,llegando a afectar seriamente la calidad de vida de los pacientes. Uno de los principales f\u00e1rmacos empleados para el tratamiento de los s\u00edndromes depresivos es al imipramina. Si bien dicho antidepresivo tric\u00edclico parece actua sobre los sistemas seroton\u00e9rgico y catecolamin\u00e9rgico, hoy d\u00edas se acepta que la hip\u00f3tesis monoamin\u00e9rgtica del mecansimo de acci\u00f3n de los antidepresivos no explica por s\u00ed s\u00f3la la eficacia terape\u00fatica de dichas drogas. Pese a la abundante informaci\u00f3n bibliogr\u00e1fica existente al respecto a tales mecanismso de acci\u00f3n son, a\u00fan, relativamente desconocidos.  existen evidencias de la posible participaci\u00f3n del sistema opioide end\u00f3geno, y m\u00e1s en concreto de las encedalinas, en la depresi\u00f3n y su tratamiento. en la presente tesis doctoral se ha tratado de a\u00f1adir algunos datos neuroqu\u00edmicos m\u00e1s a los ya existentes respecto al modo de acci\u00f3n de la imipramina. Para ello, se estudi\u00f3 el efecto de los tratamientos agudos, subcr\u00f3nicos y cr\u00f3nicos con imipramina sobre los diversos componentes implicados en la modulaci\u00f3n del sistema encefalin\u00e9rgico: las peptidasas degradadoras de encefalinas (endopeptidasa-24,11 y tirosil-aminopeptidasas) y los receptores opioides.Dicho estudio fue llevado a cabo en diversas regiones del sistema nervioso central de la rata (cortezas frontal y parietal, n\u00facleo estriado, hipot\u00e1lamo, cerebelo, y porci\u00f3n cervial de la m\u00e9dula). Los ensayos enzim\u00e1ticos para determinar el efecto de la imipramina sobre la actividad peptid\u00e1sica fueron realizados tanto ex vivo como in vitro. La afinidad y densidad de receptores opioides se determin\u00f3 por fijaci\u00f3n espec\u00edfica de (3h)-dpdpe.  la imipramina inhibi\u00f3  in vitro y de manera dosis-dependiente las actividades aminopeptid\u00e1sicas sensibles a puromicina de todas las regiones analizdas; no alternado significativamente las actividades tiros<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la imipramina sobre la modulaci\u00f3n del sistema encefalin\u00e9rgico en el sistema nervioso central de la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la imipramina sobre la modulaci\u00f3n del sistema encefalin\u00e9rgico en el sistema nervioso central de la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adolfo Varona Guti\u00e9rrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lu\u00eds Casis S\u00e1enz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  De gandarias y baj\u00f3n Juan  manuel <\/li>\n<li>Luis Garc\u00eda torres (vocal)<\/li>\n<li>eduardo Arilla ferreiro (vocal)<\/li>\n<li> Escanero marcen Jes\u00fas Fernando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adolfo Varona Guti\u00e9rrez Las patolog\u00edas depresivas son uno de los principales problemas sanitarios en los pa\u00edses desarrollados,llegando [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,3352,817,4275,12909],"tags":[185080,35773,10770,29051,13402,2200],"class_list":["post-88779","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-fisiologia-del-sistema-nervioso-central","category-fisiologia-humana","category-neurociencias","category-pais-vasco-euskal-herriko-unibertsitatea","tag-adolfo-varona-gutierrez","tag-de-gandarias-y-bajon-juan-manuel","tag-eduardo-arilla-ferreiro","tag-escanero-marcen-jesus-fernando","tag-luis-casis-saenz","tag-luis-garcia-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88779"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88779\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}