{"id":88795,"date":"2001-09-02T00:00:00","date_gmt":"2001-09-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-y-estudios-de-interaccion-de-peptidos-inmunogenicos-relacionados-con-el-virus-de-la-hepatitis-a-evaluacion-inmunologica-con-modelos-de-membrana\/"},"modified":"2001-09-02T00:00:00","modified_gmt":"2001-09-02T00:00:00","slug":"sintesis-y-estudios-de-interaccion-de-peptidos-inmunogenicos-relacionados-con-el-virus-de-la-hepatitis-a-evaluacion-inmunologica-con-modelos-de-membrana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-estudios-de-interaccion-de-peptidos-inmunogenicos-relacionados-con-el-virus-de-la-hepatitis-a-evaluacion-inmunologica-con-modelos-de-membrana\/","title":{"rendered":"Sintesis y estudios de interaccion de peptidos inmunogenicos relacionados con el virus de la hepatitis a. evaluacion inmunologica con modelos de membrana"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sospedra Alsina Patricia Pilar <\/strong><\/h2>\n<p>En la presente memoria se reportan estudios fisioqu\u00edmicos de las interacciones entre el p\u00e9ptido sint\u00e9tico correspondiente a la secuencia antigenica 110-121(110 phe-trp-arg-gly-asp-leu-val-phe-asp-phe-gln-val121) de la proteina vp3 de la c\u00e1pside del virus de la hepatitis a y los diferentes tipos de l\u00edpidos (an\u00f3nico, cati\u00f3nico y neutro) y modelos de membrana de eritrocito y hepatocito. as\u00ed mismo se realizaron estudios con otros p\u00e9ptidos an\u00e1logos: a) dos derivados sint\u00e9ticos (sustituci\u00f3n de la glicina en la posici\u00f3n 113 por lisina y sustituci\u00f3n del \u00e1cido asp\u00e1rtico en posici\u00f3n 114 por \u00e1cido glut\u00e1mico), b) dos derivados hidrof\u00f3bicos (palmitoil vp3(110-121) y derivado c-amidado y n-acetlado), c) vp3(110-121)unido a liposomas unilamenlares mediante enlace amida y d) derivados de la estructura original con menor longitud de cadena de amino\u00e1cidos. Todos los p\u00e9ptidos estudiados se caracterizaron fisicoquimicamente mediante la determinaci\u00f3n de la actividad superficial. Como modelo de membrana se emplearon pel\u00edculas monomoleculares mediante la t\u00e9cnica de langmuir, realizando cin\u00e9ticas de penetraci\u00f3n a \u00e9ra constante y isotermas de comprensi\u00f3n. tambien se emplearon bicapas lip\u00eddicas utilizando t\u00e9cnicas espectrofluorim\u00e9tricas, en ellas se evaluaron las interacciones con las bicapas utilizando las sondas fluorescentes ans y dph.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y estudios de interaccion de peptidos inmunogenicos relacionados con el virus de la hepatitis a. evaluacion inmunologica con modelos de membrana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y estudios de interaccion de peptidos inmunogenicos relacionados con el virus de la hepatitis a. evaluacion inmunologica con modelos de membrana <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sospedra Alsina Patricia Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepcion Mestres Miralles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Vilas sanchez <\/li>\n<li>oriol Valls planells (vocal)<\/li>\n<li>benito Del castillo garcia (vocal)<\/li>\n<li>Jos\u00e9 Cemeli pons (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sospedra Alsina Patricia Pilar En la presente memoria se reportan estudios fisioqu\u00edmicos de las interacciones entre el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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