{"id":88835,"date":"2001-12-02T00:00:00","date_gmt":"2001-12-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-residuos-de-marbofloxacina-en-pollos-broiler\/"},"modified":"2001-12-02T00:00:00","modified_gmt":"2001-12-02T00:00:00","slug":"farmacocinetica-y-residuos-de-marbofloxacina-en-pollos-broiler","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-y-residuos-de-marbofloxacina-en-pollos-broiler\/","title":{"rendered":"Farmacocin\u00e9tica y residuos de marbofloxacina en pollos broiler."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mcallister Tafur Garzon <\/strong><\/h2>\n<p>Se ha llevado a cabo un estudio farmacocin\u00e9tico de la fluroquinolona marbofloxacina en pollos broiler tras la administraci\u00f3n i.V. Y oral de unas dosis \u00fanica de 2mg\/kg, y un estudio de depleci\u00f3nd e residuos tras la administraci\u00f3nd e dosis de 2mg\/kg\/d\u00eda durante 3 d\u00edas consecutivos en la misma especie aviar.  tras la administraci\u00f3noral de la marbofloxacina se absorbe r\u00e1pidamente alcanzando una concentraci\u00f3n plasm\u00e1tica m\u00e1xima (cmax) de 1,05 + 0,05 ug\/ml, en un tiempo m\u00e1ximo (tmax) de 2,5 horas.  la biodisponibilidad oral encontrada fue de 58,37+2,40%. El volumen de distribuci\u00f3n en fase estacionaria (vd (ss)) obtenido tras la administraci\u00f3n i.V. De 0,77+0,09l\/kg y el volumen de distribuci\u00f3n de la fase de eliminaci\u00f3n (vd(\u00e1rea)) de 2,15+0,10 obtenido tras la administraci\u00f3n oral, indicanuna vuena distribuci\u00f3n tisular del compuesto.  la marbofloxacina fue lentamente eliminada del organismo y el valor medio del aclaramiento plasm\u00e1tico fue de 0,17l\/kg tras administraci\u00f3noral e intravenosa. En pollos, la marbofloxacina fue ampliamente metabolizada y al igual que en el plasma, el \u00fanico metabolito detectado en los tejidos tras la adminsitraci\u00f3n de una doxis de 2mg\/kg\/d\u00eda durante 3 d\u00edas fue n-demtil-marbofloxacina.  las concentraciones de marbofloxacina y su metabolito detectada en ri\u00f1\u00f3n, h\u00edgado y pulm\u00f3n tras el primer d\u00eda de retirada del tratamiento, estuvieron en un rango de 735 a 985 ug\/kg para el compuesto inalterado y de 499 a554 ug\/kg para el maetabolito.  las concentraciones detectadas en m\u00fasculo y piel + grasa se encontraron enun rango de 32 a 43 ug\/kg para el compuesto inalterado y de 119a 266 ug\/kg para el metabolito, valores inferiores al l\u00edmite m\u00e1ximo de residuso (lmr) fijado para estos dos \u00faltimos tejidos en la especie bovina y porcina (150 y 50 ug\/kg respectivamente). Tres d\u00edas tras la retirada del tratamiento los nivles de marbofloxacina en ri\u00f1\u00f3n, h\u00edgado y pulm\u00f3n fueron respectivamente, 39,7,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica y residuos de marbofloxacina en pollos broiler.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica y residuos de marbofloxacina en pollos broiler. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mcallister Tafur Garzon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Ramon Anadon Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fernandez <\/li>\n<li>Jos\u00e9 Bello gutierrez (vocal)<\/li>\n<li> Harridson de la torre arturo (vocal)<\/li>\n<li>david Ordo\u00f1ez escudero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mcallister Tafur Garzon Se ha llevado a cabo un estudio farmacocin\u00e9tico de la fluroquinolona marbofloxacina en pollos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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