{"id":88904,"date":"2018-03-10T00:13:59","date_gmt":"2018-03-10T00:13:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-del-proteola%c2%adpido-mal-en-el-transprote-polarizado-de-protea%c2%adnas-en-celulas-epiteliales\/"},"modified":"2018-03-10T00:13:59","modified_gmt":"2018-03-10T00:13:59","slug":"funcion-del-proteola%c2%adpido-mal-en-el-transprote-polarizado-de-protea%c2%adnas-en-celulas-epiteliales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/funcion-del-proteola%c2%adpido-mal-en-el-transprote-polarizado-de-protea%c2%adnas-en-celulas-epiteliales\/","title":{"rendered":"Funci\u00f3n del proteol\u00edpido mal en el transprote polarizado de prote\u00ednas en c\u00e9lulas epiteliales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Mart\u00edn Belmonte <\/strong><\/h2>\n<p>El proteol\u00edpido mal ha sido propuesto como un elemento de la maquinaria de transporte que opera en la distribuci\u00f3n apical de prote\u00ednas en c\u00e9lulas epiteliales polarizadas. El hecho de que, a diferencia de los que ocurre con las c\u00e9lulas epiteliales mdck, las c\u00e9lulas frt derivadas de tiroides de rata dirijan la mayor parte de sus prote\u00ednas ancladas por glicosilfosfatidilinositosl gpi a la membrana basolateral, nos ha suministrado una oportunidad \u00fanica para determinar el papel de mal en el transporte apical de prote\u00ednas de membrana en condiciones en las que la mayor\u00eda de prote\u00ednas ancladas  por gpi don (mdck) o no (frt) transportadas a la membrana apical. Utilizando una estrategia basada en oligonucle\u00f3tidos antisentido para reducir los niveles de la prote\u00edna mal end\u00f3gena, hemos observado que el transporte correcto de prote\u00ednas transmembrana apicales asociadas con rafts (ha y al prote\u00edna anclada por gpi gd1-daf) o no (el receptor neurotr\u00f3fico p75ntr ex\u00f3geno), as\u00ed como el conjunto de prote\u00ednas end\u00f3genas de membrana destinadas a la membrana apical dependen de unos niveles normales de prote\u00edan mal end\u00f3gena. De igual forma, el transporte correcto de ha, p75ntr, dppiv y el conjunto de prote\u00ednas apicales de membrana end\u00f3genas tiene lugar por una ruta que es dependiente de unos niveles normales de la prote\u00edna ancladas por gpi que son  transportadas a la membrana apical en las c\u00e9lulas frt, es dependiente de unos niveles normales de mal end\u00f3geno, mientras que no se afect\u00f3 el transporte basolateral de gd1-daf cuando se redujeron los niveles de mal end\u00f3geno en estas c\u00e9lulas.  hemos demostrado, adem\u00e1s, que la prote\u00edna secretada tiroglobulina es transportada a la superficie apical por una ruta asociada a rafts y que tanto tiroglobulina como la prote\u00edna end\u00f3gena secretada apicalmente gp80 dependen de mal para su secreci\u00f3n en las c\u00e9lulas mdck.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n del proteol\u00edpido mal en el transprote polarizado de prote\u00ednas en c\u00e9lulas epiteliales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n del proteol\u00edpido mal en el transprote polarizado de prote\u00ednas en c\u00e9lulas epiteliales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Mart\u00edn Belmonte <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Alonso Lebrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>m\u00f3nica Marazuela azpiroz (vocal)<\/li>\n<li>ignacio Vicente-sandoval rodr\u00edguez (vocal)<\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Mart\u00edn Belmonte El proteol\u00edpido mal ha sido propuesto como un elemento de la maquinaria de transporte [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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