{"id":88929,"date":"2018-03-10T00:13:59","date_gmt":"2018-03-10T00:13:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-farmacologica-y-molecular-de-los-receptores-de-la-familia-5-ht2-de-la-serotonina-en-cerebro-de-mamiferos\/"},"modified":"2018-03-10T00:13:59","modified_gmt":"2018-03-10T00:13:59","slug":"caracterizacion-farmacologica-y-molecular-de-los-receptores-de-la-familia-5-ht2-de-la-serotonina-en-cerebro-de-mamiferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-farmacologica-y-molecular-de-los-receptores-de-la-familia-5-ht2-de-la-serotonina-en-cerebro-de-mamiferos\/","title":{"rendered":"Caracterizacion farmacologica y molecular de los receptores de la familia 5-ht2 de la serotonina en cerebro de mamiferos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lopez Gimenez Juan  F. <\/strong><\/h2>\n<p>El objetivo general de la presenta tesis fue la caracterizaci\u00f3n farmacol\u00f3gica de los receptores pertenecientes a la familia 5-ht2 de la serotonina, asi como el estudio de su distribuci\u00f3n anat\u00f3mica en el cerebro de mamiferos. para la consecuci\u00f3n de estos objetivos se emplearon fundamentalmente tecnicas autorradiograficas, como la autorradiografia de receptores o la hibridaci\u00f3n in situ. En primer lugar, se caracteriz\u00f3 el [3h] mdl100,907 para su uso como radioligando en estudios de autorradiografia de receptores, llegando a la conclusi\u00f3n de que el [3h]mdl 100,907 es el mejor radioligando en la actualidad para visualizar de forma selectiva los receptores 5-ht2a en cerebro de rata, mono y humano.  posteriormente se examin\u00f3 la distribuci\u00f3n de los receptores 5-ht2a y 5-ht2c en cerebro de mono empleando [3h]mdl100,907 y [3h] mesulergina respectivamente como radioligandos, al mismo tiempo que se usaron sondas de oligonucleotidos para la visualizacion del arnm que codifica para cada subtipo de receptor. ambos receptores distribuyen de forma heterog\u00e9nea en cerebro de mono, presentando cada subtipo una distribuci\u00f3n caracter\u00edstica. El patr\u00f3n de distribuci\u00f3n observando en los experimentos de autoradiografia de receptores para ambos subtipos de receptores coincid\u00eda con la se\u00f1al de hibridaci\u00f3n obtenida en los estudios llevados a cabo con las correspondientes sondas de oligonucle\u00f3tidos, sugirieron que ambos subtipos de receptores, 5-ht2a y 5-ht2c, presentan predominantemente una localizaci\u00f3n celular somatodendr\u00edtica.  otro estudio autorradiogr\u00e1fico realizado en esta tesis fue el analisis de la posible alteraci\u00f3n de diferentes subtipos de receptores de serotonina as\u00ed como del transportador de serotonina en cerebro de ratones \u00abknockout\u00bb para el receptor 5-ht2c. No se observaron alteraciones significativas en las densidades de los sitios de uni\u00f3n de los diferentes radioligandos utilizados, a excepci\u00f3n de aquellos que se unen al subt<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion farmacologica y molecular de los receptores de la familia 5-ht2 de la serotonina en cerebro de mamiferos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion farmacologica y molecular de los receptores de la familia 5-ht2 de la serotonina en cerebro de mamiferos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lopez Gimenez Juan  F. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guadalupe Mengod Los Arcos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Cadavid torres <\/li>\n<li>\u00e1ngel Pazos carro (vocal)<\/li>\n<li>Rafael Rodriguez puertas (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lopez Gimenez Juan F. El objetivo general de la presenta tesis fue la caracterizaci\u00f3n farmacol\u00f3gica de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,212,160,35,9,957,561,183,8868,4275,39702,17],"tags":[2579,26390,185332,2449,26389],"class_list":["post-88929","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-humana","category-bioquimica","category-ciencias-de-la-vida","category-ciencias-medicas","category-farmacologia","category-farmacologia-molecular","category-farmacos-psicotropicos","category-neuroanatomia-humana","category-neurociencias","category-neuroquimica","category-quimica","tag-angel-pazos-carro","tag-guadalupe-mengod-los-arcos","tag-lopez-gimenez-juan-f","tag-maria-isabel-cadavid-torres","tag-rafael-rodriguez-puertas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=88929"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/88929\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=88929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=88929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=88929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}