{"id":88960,"date":"2018-03-10T00:14:03","date_gmt":"2018-03-10T00:14:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/resistencia-del-reovirus-aviar-hacia-el-interferon-implicacion-de-la-protea%c2%adna-sigma-a\/"},"modified":"2018-03-10T00:14:03","modified_gmt":"2018-03-10T00:14:03","slug":"resistencia-del-reovirus-aviar-hacia-el-interferon-implicacion-de-la-protea%c2%adna-sigma-a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/resistencia-del-reovirus-aviar-hacia-el-interferon-implicacion-de-la-protea%c2%adna-sigma-a\/","title":{"rendered":"Resistencia del reovirus aviar hacia el interfer\u00f3n: implicaci\u00f3n de la prote\u00edna sigma a."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Claudia Gonzalez Lopez <\/strong><\/h2>\n<p>Los reovirus aviares son los agentes responsables de numerosas patolog\u00edas en aves de granja, las cuales originan importantes p\u00e9rdidas econ\u00f3micas a la industria av\u00edcola. A pesar de su gran importancia c\u00f3mo pat\u00f3ngenos, se conoce muy poco sobre los aspectos b\u00e1sicos de la biolog\u00eda de los reovirus aviares. Desde hace varios a\u00f1os, en nuestro laboratorio se est\u00e1 llevando a cabo una caracterizaci\u00f3n bioqu\u00edmica profunda de estos agentes, lo que creemos que permitir\u00e1 sentar las bases para dise\u00f1ar sistemas de diagn\u00f3stico, serotipaje y producci\u00f3n de vacunas, con el fin \u00faltimo de prevenir y\/o combatir las enfermedades inducidas por estos agentes.  con la realizaci\u00f3n de esta tesis nos propusimos estudiar la sensibilidad del reovirus aviar s1133 frente a la acci\u00f3n antiviral del interfer\u00f3n y determinar los mecanismos que utiliza el virus para contrarrestar la acci\u00f3n antiviral del intefer\u00f3n. En primer lugar, demostramos que el reovirus aviar s1133, pero no el virus vaccinia o el virus de la estomatitis vesicular, es resistente a la acci\u00f3n antiviral de un intefer\u00f3na viar recombinante enfibroblastos ambrionarios de pollo. A continuaci\u00f3n, observamos que los extractos de c\u00e9lulas infectas con reovirus aviar, pero no los de c\u00e9lulas sin infectar, bloquean la activaci\u00f3n de las enzimas dependientes de dsrna en extractos de reticulocito de conejo, y que esa actividad bloqueante radicaba en la prote\u00edna viral oa, una prote\u00edna del core viral con una gran afinidad de uni\u00f3n a rna de doble cadena. El gen que codifica oa se clon\u00f3 en un vector de expresi\u00f3n procariota, y tambi\u00e9n se gener\u00f3 un virus vaccinia recombinante que expresa dicha prote\u00edna. La expresi\u00f3n de oa, a partir del virus vaccinia recombiannte wrs2, protege el virus vaccinia de la actividad antiviral del intrefer\u00f3n e inhibe la activaci\u00f3n de la prote\u00edna quinasa dependiente de rna de doble cadena, probablemente secuestrando el dsrna activador. En conjunto, todos estos resulta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Resistencia del reovirus aviar hacia el interfer\u00f3n: implicaci\u00f3n de la prote\u00edna sigma a.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Resistencia del reovirus aviar hacia el interfer\u00f3n: implicaci\u00f3n de la prote\u00edna sigma a. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Claudia Gonzalez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Benavente Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: germ\u00e1n Sierra marcu\u00f1o <\/li>\n<li> Rodr\u00edguez aguirre Jos\u00e9 Francisco (vocal)<\/li>\n<li>tom\u00e1s Gonz\u00e1lez villa (vocal)<\/li>\n<li>angel Reflero chillon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Claudia Gonzalez Lopez Los reovirus aviares son los agentes responsables de numerosas patolog\u00edas en aves de granja, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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