{"id":88973,"date":"2018-03-10T00:14:03","date_gmt":"2018-03-10T00:14:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/preparacion-de-microesferas-de-ibuprofeno-para-administracion-intraarticular\/"},"modified":"2018-03-10T00:14:03","modified_gmt":"2018-03-10T00:14:03","slug":"preparacion-de-microesferas-de-ibuprofeno-para-administracion-intraarticular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/preparacion-de-microesferas-de-ibuprofeno-para-administracion-intraarticular\/","title":{"rendered":"Preparaci\u00f3n de microesferas de ibuprofeno para administraci\u00f3n intraarticular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana M Fernandez  Carballido <\/strong><\/h2>\n<p>Se lleva a cabo la elaboraci\u00f3n de microesferas biodegradables de ibuprofeno que liberen el principio activo de forma sostenida en el tiempo, y destinadas a su administraci\u00f3n por v\u00eda intraarticular, buscando un efecto antiinflamatorio local y de esta forma minimizar los efectos adversos producidos como consecuencia de su utilizaci\u00f3n sist\u00e9mica.  la t\u00e9cnica de microencapsulaci\u00f3n utilizada es la de evaporaci\u00f3n de solvente a partir de una emulsi\u00f3n o\/a.  se analiza la influencia del peso molecular del pol\u00edmero sobre las caracter\u00edsticas de las microesferas, se comparan los proceso de liofilizaci\u00f3n y desecaci\u00f3n y se analizan la influencia de un aditivo de naturaleza oleosa sobre los perfiles de cesi\u00f3n del f\u00e1rmaco a partir de las microesferas.  se optimiza la formulaci\u00f3n mediante dise\u00f1o factorial y se selecciona aquellas que pudiera proporcionar niveles  eficaces de ibuprofeno en l\u00edquido sinovial durante un periodo de tiempo no inferior a siete d\u00edas. por \u00faltimo, y en la formulaci\u00f3n seleccionada, se comprueba que en las condiciones de almacenamiento durante un a\u00f1o no se precian modificaciones en los perfiles de cesi\u00f3n del principio activo, ni se han producido  variaciones importantes en el peso molecular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Preparaci\u00f3n de microesferas de ibuprofeno para administraci\u00f3n intraarticular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Preparaci\u00f3n de microesferas de ibuprofeno para administraci\u00f3n intraarticular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana M Fernandez  Carballido <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M Pilar Pastoriza  Abal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>carmen Mar\u00eda Evora Garc\u00eda (vocal)<\/li>\n<li>Ana isabel Ortiz  gutierrez (vocal)<\/li>\n<li>Manuel Guzm\u00e1n navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana M Fernandez Carballido Se lleva a cabo la elaboraci\u00f3n de microesferas biodegradables de ibuprofeno que liberen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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