{"id":89000,"date":"2018-03-10T00:14:03","date_gmt":"2018-03-10T00:14:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-polimorfismo-de-los-genes-cd1-en-humanos\/"},"modified":"2018-03-10T00:14:03","modified_gmt":"2018-03-10T00:14:03","slug":"analisis-del-polimorfismo-de-los-genes-cd1-en-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-del-polimorfismo-de-los-genes-cd1-en-humanos\/","title":{"rendered":"Analisis del polimorfismo de los genes cd1 en humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Oteo Vives <\/strong><\/h2>\n<p>El sistema cd1 es un conjunto de mol\u00e9culas relacionados con hla de clase i implicadas en la presentaci\u00f3n de l\u00edpidos y glicol\u00edpidos de microbacterias a los linfocitos t.  en este trabajo se realiza un an\u00e1lisis del polimorfismo de los cinco genes cd1 humanos de forma exhaustiva por pcr y sscp. Se describen 4 nuevos alelos de cd1 en individuos sanos de distinto origen \u00e9tnico. Uno de estos alelos resulta de un cambio de cys por trp en el triplete 52 de cd1a y su frecuencia var\u00eda desde un 10% en individuos caucasoides a un 50% en mongoloides.  con el fin de caracterizar estructuralmente dicho alelo, el c-dna que codifica la secuencia completa de los alelos salvaje y mutado de cd1a se transfect\u00f3 en l\u00edneas celulares deficientes de hla de clase i demostr\u00e1ndose que ambos alelos eran capaces de expresarse en la membrana de las c\u00e9lulas transfectadas. Mediante inmunoprecipitaci\u00f3n y posterior electroforesis en condiciones reductoras y no reductoras se comprueba que cd1 se encuentra en forma monom\u00e9rica en la superficie de dichas c\u00e9lulas.  as\u00ed mismo, se analizan los genes cd1 en una serie de pacientes que presentan una serie de infecciones por micobacterias no tuberculoides en ausencia de inmunodeficiencias conocidas. Nuestros resultados indican que estos pacientes no presentan alteraciones enlos genes cd1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis del polimorfismo de los genes cd1 en humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis del polimorfismo de los genes cd1 en humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Oteo Vives <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Martinez Naves<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>segundo Gonzalez lopez (vocal)<\/li>\n<li>Jos\u00e9 Luis Vicario  moreno (vocal)<\/li>\n<li>Carlos Lopez larrea (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Oteo Vives El sistema cd1 es un conjunto de mol\u00e9culas relacionados con hla de clase i [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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